Gatifloxacin + Dexamethasone
Indications
Gatifloxacin + Dexamethasone is used for inflammatory conditions of the eye that respond to steroids and also involve bacteria. These include blepharitis, scleritis, episcleritis, iritis, cyclitis, iridocyclitis, choroiditis, optic neuritis and chronic anterior uveitis. It also helps in disciform and interstitial keratitis, allergic corneal marginal ulcers, and corneal injury from chemical, radiation or thermal burns.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Gatifoxacin works against bacteria by blocking two enzymes, DNA gyrase and topoisomerase IV. DNA gyrase is essential for bacterial DNA to be copied, read and repaired. Topoisomerase IV is known to play a key role in separating the chromosomal DNA when a bacterial cell divides. Because Gatifoxacin stops this process, it kills the bacteria (it is bactericidal).
Dexamethasone acts by blocking phospholipase A2, which is the first step in making prostaglandins. It also stops neutrophils from moving into the site of inflammation. Its anti-inflammatory activity is 30 times greater than that of hydrocortisone, and its overall therapeutic effectiveness is 8-10 times greater. Like other glucocorticoids, Dexamethasone is anti-allergic, anti-exudative and anti-proliferative.
Pregnancy & Breastfeeding
In Pregnancy: There are no adequate and well-controlled studies in pregnant women, so these Gatifloxacin and Dexamethasone eye drops should be used during pregnancy only if the possible benefit justifies the possible risk to the fetus.
In Lactation: Gatifloxacin and Dexamethasone have not been measured in human milk, although it can be presumed that they pass into human milk after topical use. Take caution when the combination is given to a nursing woman.
Pediatric Use: The safety of the combination in pediatric patients has not been established.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.