Indications
Fusidic acid + Betamethasone cream is used for eczema and dermatitis that have a secondary infection. This covers atopic dermatitis, allergic dermatitis, seborrhoeic dermatitis and primary irritant dermatitis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Fusidic acid works only against gram-positive bacteria, such as Streptococcus, Staphylococcus aureus and Corynebacterium minutissimum. It kills these bacteria by stopping them from making protein. The drug interferes with the transfer of amino acids from aminoacyl-tRNA to protein on the ribosomes.
Betamethasone induces lipocortin, and lipocortin inhibits the phospholipase A-2 enzyme. This blocks the synthesis of several inflammatory mediators, like prostaglandins, cinins and histamines.
Pharmacokinetics
Fusidic acid can penetrate intact human skin. As much as 2% of the amount applied to the skin goes through it. How much penetrates depends on things like how long the skin is exposed to fusidic acid and the condition of the skin. Fusidic acid is excreted mainly in the bile, and only a little leaves in the urine.
For any topical corticosteroid, including betamethasone, skin absorption and potency depend on the vehicle that carries the steroid. Betamethasone may be absorbed more in certain parts of the body, such as the face, groin or axilla. The same is true on injured or inflamed skin, such as the lesions of atopic dermatitis.
Pregnancy & Breastfeeding
Don't use fusidic acid and betamethasone in pregnancy. Both ingredients have been found in breast milk, so mothers who are nursing are advised not to use this medicine either.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.