Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 23 hours ago

Indications

Follitropin Beta Cartridge is used in women for induction of ovulation and pregnancy in anovulatory infertile women in whom the cause of infertility is functional and not due to primary ovarian failure. Prior checks are needed before starting treatment with Follitropin Beta Cartridge. The woman should have a complete gynecologic and endocrinologic evaluation. Primary ovarian failure should be excluded, and so should the possibility of pregnancy. Tubal patency should be demonstrated, and the fertility status of the male partner should be evaluated. It is also used for pregnancy in normal ovulatory women undergoing controlled ovarian stimulation as part of an In Vitro Fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) cycle. Here too, prior evaluation is needed before treatment begins. Women should have a complete gynecologic and endocrinologic evaluation and a diagnosis of the cause of infertility. The possibility of pregnancy should be excluded, and the fertility status of the male partner should be evaluated. In men, Follitropin Beta Cartridge is used for induction of spermatogenesis in men with primary and secondary Hypogonadotropic Hypogonadism (HH) in whom the cause of infertility is not due to primary testicular failure. Before treatment starts, men should have a complete medical and endocrinologic evaluation. Hypogonadotropic hypogonadism should be confirmed and primary testicular failure should be excluded. Serum testosterone levels should be normalized with human chorionic gonadotropin (hCG) treatment. The fertility status of the female partner should also be evaluated.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Women

Follicle-stimulating hormone (FSH) is the active component in Follitropin Beta Cartridge, and the body needs it for normal follicular growth, maturation and the production of gonadal steroids. In women, the FSH level matters a great deal for when follicular development starts and how long it lasts. That in turn decides the timing and the number of follicles that reach maturity. Follitropin Beta Cartridge stimulates ovarian follicular growth in women who do not have primary ovarian failure. Final follicle maturation, the resumption of meiosis and the rupture of the follicle all need to happen, and without an endogenous LH surge they won't happen on their own. So human chorionic gonadotropin (hCG) must be given after treatment with Follitropin Beta Cartridge, once patient monitoring shows that the right follicular development parameters have been reached.

Men

When Follitropin Beta is given together with hCG, it stimulates spermatogenesis in men with hypogonadotropic hypogonadism. FSH, the active component of Follitropin Beta, is the pituitary hormone responsible for spermatogenesis.

Pregnancy & Breastfeeding

Pregnancy: Follitropin Beta Cartridge must not be used in pregnant women, and it gives no benefit during pregnancy.

Lactation: Doctors don't know whether this medicine passes into human milk. So the benefits of breastfeeding for the baby's development and health should be weighed against the mother's clinical need for Follitropin Beta Cartridge. Any possible side effects on the breastfed child, whether from the medicine or from the mother's underlying condition, should be considered as well.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: In Anovulatory Women Undergoing Ovulation Induction The starting dose is 50 international units of Follitropin Beta Cartridge once a day, given subcutaneously, for at least the first 7 days. After that, the dose is increased by 25 or 50 international units at weekly intervals until follicular growth and/or serum estradiol levels show an adequate response. When an acceptable pre-ovulatory state is reached, final oocyte maturation is brought about with 5,000 to 10,000 international units of urinary human chorionic gonadotropin (hCG). The woman and her partner should have intercourse daily, starting on the day before hCG is given and continuing until ovulation becomes apparent. In Normal Ovulatory Women Undergoing Controlled Ovarian Stimulation as Part of an In Vitro Fertilization or Intracytoplasmic Sperm Injection Cycle The starting dose is 200 international units (actual cartridge doses) of Follitropin Beta Cartridge, given subcutaneously for at least the first 7 days of treatment. Later doses can be adjusted down or up depending on ovarian response, as judged by ultrasound evaluation of follicular growth and serum estradiol levels. For high responders, the dose can be reduced from the 6th day of treatment onward, according to individual response. Final oocyte maturation is induced with 5,000 to 10,000 international units of urinary hCG. Oocyte (egg) retrieval is done 34 to 36 hours later. Induction of Spermatogenesis in Men Pretreatment with urinary hCG alone (1,500 international units twice weekly) is required. If serum testosterone levels have not normalized after 8 weeks of hCG treatment, the dose may be increased to 3,000 international units twice a week. Once serum testosterone levels have normalized, Follitropin Beta Cartridge is given at 450 international units per week (225 international units twice weekly or 150 international units three times weekly).