Fluocinolone Acetonide + Neomycin Sulfate
Indications
Fluocinolone Acetonide + Neomycin Sulfate cream or ointment can be used on many local inflammatory, itchy (pruritic) and allergic skin disorders. It is applied directly to the skin, and it suits these conditions in particular. For eczema and dermatitis, these include atopic eczema, seborrhoeic eczema, discoid eczema, otitis externa, contact dermatitis and neurodermatitis. It is also used for prurigo, psoriasis, lichen planus and discoid lupus erythematosus. Skinalar-N cream or ointment is used in the same way. The combination is indicated for inflammatory dermatoses where a secondary bacterial infection is already present or is likely to occur.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Fluocinolone acetonide is a corticosteroid, used mainly in dermatology to reduce skin inflammation and relieve itching. It is a synthetic derivative of hydrocortisone. It was also found to strongly boost TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, raising the levels of collagen type II by more than 100 fold compared to dexamethasone, which is widely used.
Neomycin Sulfate is actively transported across the bacterial cell membrane. Inside the cell, it binds to a specific receptor protein on the 30 S subunit of the bacterial ribosomes and interferes with an initiation complex between mRNA (messenger RNA) and the 30 S subunit. This stops the bacteria from making protein.
Pregnancy & Breastfeeding
When corticosteroids were applied to the skin of pregnant animals, they caused abnormal development of the fetus, including cleft palate and intrauterine growth retardation. There may be a small risk of the same effects on a human fetus. So if a topical steroid like Fluocinolone Acetonide + Neomycin Sulfate has to be used during pregnancy, keep both the amount and the length of treatment as low as possible.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.