Community data Updated 2 months ago

Fluconazole

Drugs for subcutaneous and mycoses Prescription

Indications

Fungal Infection Vaginal Candidiasis Cancer

Fungicap is used in vaginal candidiasis, oropharyngeal candidiasis and esophageal candidiasis. It is also used for tinea corporis, tinea cruris, tinea pedis and other tinea, as well as kerion, pityriasis versicolor and onychomycosis. Other uses are invasive candidal infections and cryptococcal infections, including meningitis, and the prevention of cryptococcal meningitis. Fungicap is also given to prevent fungal infections in immunocompromised patients. The text separates its uses into superficial candidiasis, and systemic candidiasis and cryptococcal infection, but gives no further detail under either. Fungicap has some other indications too. These are fungal urinary tract infections, disseminated candidiasis, and prophylaxis for fungal infection in neutropenic cancer patients. It is also used for the acute treatment of other systemic fungal infections such as coccidioidomycosis and histoplasmosis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Fluconazole belongs to the triazole class of antifungal medicines. It works by strongly blocking certain fungal enzymes that depend on cytochrome P-450, a system that forms an essential part of the fungal cell membrane and is needed to produce ergosterol.

Pregnancy & Breastfeeding

Fluconazole has caused harmful effects on the fetus in animal studies, but only at doses far higher than those used to treat humans, and only when the dose was also toxic to the mother. Very little data exist on its use during human pregnancy. For this reason, fluconazole should be avoided during pregnancy and by women who could become pregnant, unless reliable contraception is being used.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults: Vaginal Candidiasis: 150 mg as a single dose. Oropharyngeal Candidiasis: 200 mg on the first day followed by 100 mg daily for 14 days. Oesophageal Candidiasis: 200 mg on the first day followed by 100 mg daily for 14 to 30 days. Tinea corporis, Tinea cruris, Tinea pedis and Other Tinea: 150 mg weekly for 4 to 6 weeks. Kerion: 50 mg daily for 20 days. Pityriasis versicolor: 400 mg as a single dose. Onychomycosis: 150 mg weekly for 12 months. Invasive candidal infections and cryptococcal infections, including meningitis: given orally or by IV infusion, 400 mg on the first day then 200 to 400 mg daily. Prevention of cryptococcal meningitis: given orally or by IV infusion, 200 mg daily. Prevention of fungal infections in immunocompromised patients: given orally or by IV infusion, 50 to 400 mg daily. Children over 1 year: In Superficial Candidiasis, 1 to 2 mg per kg daily. In Systemic Candidiasis and Cryptococcal infection, 3 to 6 mg per kg daily. In serious life threatening infections, up to 12 mg per kg daily has been given to children aged 5 to 13 years, with a maximum of 400 mg daily. As a rough guide, a child of 1 year weighing about 9 kg may be given half a measuring spoonful, a child of 1 to 2 years weighing about 12 kg one measuring spoonful, a child of 2 to 3 years weighing about 14 kg one and a half measuring spoonfuls, a child of 3 to 4 years weighing about 16 kg two measuring spoonfuls, and a child of 4 to 6 years weighing about 20 kg two and a half measuring spoonfuls. Use in specific populations. Elderly patients: the normal dose should be used if there is no evidence of renal impairment. Renal impairment: no adjustment is needed for single dose therapy. In multiple dose therapy for patients with renal impairment, normal doses should be given on days 1 and 2 of treatment, and thereafter the dosing interval should be adjusted according to creatinine clearance. With creatinine clearance above 41 ml per minute, dose every 24 hours. With creatinine clearance of 21 to 40 ml per minute, dose every 48 hours. With creatinine clearance of 10 to 20 ml per minute, dose every 72 hours. Patients on regular dialysis should receive one dose after every dialysis session. In children, renal clearance may be proportionately more rapid than in adults, and doses up to 12 mg per kg are recommended.

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Fluconazole

Indications

Pharmacology

Pregnancy & Breastfeeding

Dosage Reference

Side Effects & Interactions

Side Effects

Key Interactions