Ferric Derisomaltose

Indications

Anemia

Ferric Derisomaltose is an iron replacement product used to treat iron deficiency anemia in adults. It is given to adults who can't tolerate oral iron or who haven't responded well to oral iron. It is also used in adults who have non-hemodialysis dependent chronic kidney disease.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ferric derisomaltose is an iron replacement product given by intravenous infusion. The ferric derisomaltose in it is an iron carbohydrate complex with a matrix structure, built from interchanging layers of ferric hydroxide and a carbohydrate called derisomaltose.

Derisomaltose is made of linear, hydrogenated isomaltooligosaccharides. Their average molecular weight is 1000 Da, and the molecular weight distribution is narrow, with almost no mono- and disaccharides present. So ferric derisomaltose is a complex of iron (III) hydroxide and derisomaltose, an iron carbohydrate oligosaccharide that releases iron. The released iron binds to transferrin, which carries it to erythroid precursor cells, where it is incorporated into hemoglobin.

Pregnancy & Breastfeeding

There are no data on the use of Ferric Derisomaltose in pregnant women that could show whether it carries a risk of major birth defects, miscarriage, or harmful outcomes for the mother or the baby. Published studies of intravenous iron products in pregnant women have not reported any link with adverse developmental outcomes. But these studies can't confirm or rule out a drug-related risk during pregnancy, because they were not designed to look at the risk of major birth defects.

For breastfeeding, the data on Ferric Derisomaltose in lactating women show that iron is present in breast milk. The data don't tell us how much iron the breastfed child may be exposed to, or what effect the medicine has on milk production. The mother's clinical need for Ferric Derisomaltose should be weighed against the developmental and health benefits of breastfeeding. Any possible adverse effects on the breastfed child, whether from the medicine or from the mother's underlying condition, should also be considered.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For patients who weigh 50 kg or more, Ferric Derisomaltose is given as 1,000 mg by intravenous infusion over at least 20 minutes, as a single dose. If iron deficiency anemia comes back, the dose can be repeated. For patients who weigh less than 50 kg, the dose is 20 mg/kg of actual body weight, again by intravenous infusion over at least 20 minutes as a single dose. If iron deficiency anemia comes back, the dose can be repeated. The dose of Ferric Derisomaltose is expressed in mg of elemental iron. Each mL contains 100 mg of elemental iron. Give Ferric Derisomaltose only where staff and treatments are immediately available to manage serious hypersensitivity reactions.