Indications
Eribulin Mesylate is used for patients with metastatic breast cancer who have already received at least two chemotherapy regimens for the metastatic disease. Their earlier treatment should have included an anthracycline and a taxane, given either in the adjuvant setting or in the metastatic setting. It is also used for liposarcoma that can't be removed by surgery (unresectable) or has spread (metastatic), in patients who have previously had a regimen containing an anthracycline.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Eribulin stops microtubules from growing, but it doesn't affect their shortening phase. It also gathers tubulin into clumps that can't do any useful work. Its action is antimitotic and based on tubulin. This blocks the cell cycle at the G2/M stage and breaks up the mitotic spindles, and after the cells stay blocked in mitosis for a long time, they die by apoptosis.
Eribulin also acted on human breast cancer cells in other ways. In laboratory (in vitro) studies, treated cells changed in shape and in gene expression, and they migrated and invaded less.
In mouse xenograft models of human breast cancer, eribulin treatment was linked with more blood flow (vascular perfusion) and more permeability in the core of the tumour. This reduced hypoxia in the tumour. The genes expressed in tumour samples also changed, in a way associated with a change in phenotype.
Pregnancy & Breastfeeding
Animal reproduction studies and the way Eribulin works both suggest that it can harm the unborn baby when given to a pregnant woman. There are no data on the use of Eribulin during pregnancy.
Nothing is known about whether eribulin mesylate or its metabolites pass into human milk. The effects on a breastfed infant and on milk production are also not known. No lactation studies were done in animals.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.