Enzalutamide

Adults: The recommended dose of Enzalutamide is 160 mg taken by mouth once a day, with or without food. Swallow the capsules or tablets whole. Don't chew, dissolve or open the capsules, and don't cut, crush or chew the tablets. Dosage Modifications for Adverse Reactions If a patient has a ≥Grade 3 adverse reaction, or one they can't tolerate, Enzalutamide should be withheld for one week or until symptoms improve to ≤Grade 2. After that, treatment can restart at the same dose or at a reduced dose (120 mg or 80 mg) if warranted. Strong CYP2C8 Inhibitors Avoid giving Enzalutamide together with strong CYP2C8 inhibitors. If they can't be avoided, reduce the Enzalutamide dose to 80 mg once daily. If the strong inhibitor is later stopped, increase Enzalutamide back to the dose used before the inhibitor was started. Strong CYP3A4 Inducers Avoid giving Enzalutamide together with strong CYP3A4 inducers. If they can't be avoided, increase the Enzalutamide dose from 160 mg to 240 mg orally once daily. If the strong inducer is later stopped, decrease Enzalutamide to the dose used before the inducer was started. Pediatric Use The safety and effectiveness of Enzalutamide in children have not been established. Renal Impairment No dose change is recommended for patients with mild to moderate renal impairment. Hepatic Impairment No dose change is recommended for patients with mild, moderate or severe hepatic impairment.