Empagliflozin + Metformin Hydrochloride

Adults: The dose of this Empagliflozin and Metformin Hydrochloride combination should be set for each patient, based on how well it works and how well it is tolerated. Take it twice daily with meals. Raise the dose gradually, so the gastrointestinal side effects caused by Metformin Hydrochloride are reduced. The maximum recommended daily dose is 2000 mg for Metformin Hydrochloride and 25 mg for Empagliflozin. For the starting dose, the choice depends on what the patient already takes. A patient on Metformin Hydrochloride switches to the combination containing Empagliflozin 5 mg, with a similar total daily dose of Metformin Hydrochloride. A patient on Empagliflozin switches to the combination containing Metformin Hydrochloride 500 mg, with a similar total daily dose of Empagliflozin. A patient already treated with Empagliflozin and Metformin Hydrochloride as separate medicines switches to the combination with the same total daily dose of each. If a patient has volume depletion and hasn't been treated with Empagliflozin before, correct this before starting the combination. For extended-release formulations, the starting dose depends on the patient's current drug regimen. The film coated tablet is taken twice daily with a meal. The extended-release formulation is taken once daily with a meal. In both cases the dose goes up gradually, to reduce the GI adverse effects of Metformin. Adjust the dose according to effectiveness and tolerability, and don't go above the maximum recommended daily dose of Metformin Hydrochloride 2000 mg and Empagliflozin 25 mg. In patients with impaired kidney function, assess renal function before starting the combination. It is contraindicated in patients with an eGFR below 45 mL/min/1.73 m2. For pediatric patients under 18 years of age, safety and effectiveness have not been established.