Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Neuropathic Pain Pain Depression Anxiety

Duloxetine Hydrochloride is a serotonin and norepinephrine reuptake inhibitor (SNRI). Doctors use it for Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Diabetic Peripheral Neuropathic Pain (DPNP), Fibromyalgia and Chronic Musculoskeletal Pain.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Duloxetine Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) that you take by mouth. It also inhibits dopamine reuptake, but less strongly. In vitro, Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate and GABA receptors, and it does not inhibit monoamine oxidase (MAO).

When taken by mouth, Duloxetine hydrochloride is well absorbed. The body clears it mainly through metabolism in the liver.

Pregnancy & Breastfeeding

Pregnancy: Duloxetine is Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so it should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Labor and Delivery: The effect of Duloxetine on labor and delivery in humans is unknown. It should be used during labor and delivery only if the potential benefit justifies the potential risk to the fetus.

Lactation: It is unknown whether Duloxetine or its metabolites pass into human milk. Even so, nursing while on Duloxetine is not recommended.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Duloxetine in Major Depressive Disorder (MDD) starts at 40 mg/day to 60 mg/day. In the acute phase the target is 40 mg/day (20 mg twice daily) to 60 mg/day, which can be taken once daily or as 30 mg twice daily. For maintenance the target is 60 mg/day, and the maximum dose is 120 mg/day. In Generalized Anxiety Disorder (GAD), the starting dose is 60 mg/day. The target is also 60 mg/day, taken once daily, and the maximum is 120 mg/day. For Diabetic Peripheral Neuropathic Pain (DPNP), treatment starts at 60 mg/day. The target is 60 mg/day (once daily) and the maximum is 60 mg/day. Fibromyalgia starts at 30 mg/day. The target is 60 mg/day (once daily), and the maximum is 60 mg/day. Chronic musculoskeletal pain follows the same pattern. The starting dose is 30 mg/day, the target is 60 mg/day (once daily) and the maximum is 60 mg/day. Some patients may benefit from starting at 30 mg once daily. There is no evidence that doses greater than 60 mg/day give any additional benefit, and some adverse reactions were seen to be dose-dependent. When duloxetine is to be stopped, a gradual dose reduction is recommended to avoid discontinuation symptoms.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.