Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
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Community data Updated 23 hours ago
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Indications

Type 2 Diabetes Mellitus Diabetes Mellitus

Dulaglutide SC Injection is a glucagon-like peptide-1 (GLP-1) receptor agonist. It is used alongside diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is also used to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus who have established cardiovascular disease or multiple cardiovascular risk factors.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Dulaglutide is a human GLP-1 receptor agonist. Its amino acid sequence is 90% homologous to that of endogenous human GLP-1 (7-37). The medicine activates the GLP-1 receptor, a membrane-bound receptor on the cell surface that is coupled to adenylyl cyclase in the pancreatic beta cells. This raises intracellular cyclic AMP (cAMP) in the beta cells, and that leads to glucose-dependent insulin release. Dulaglutide also lowers glucagon secretion and slows gastric emptying.

Pregnancy & Breastfeeding

Dulaglutide should be used in pregnancy only if the possible benefit justifies the possible risk to the fetus. There are no data on whether dulaglutide passes into human milk, what it does to a breastfed infant, or whether it affects milk production. Nobody has determined if it appears in the milk of treated animals either.

If a breastfeeding mother needs dulaglutide, the developmental and health benefits of breastfeeding should be weighed alongside her clinical need for the medicine. The weighing should also cover any possible adverse effects on the breastfed infant, whether from dulaglutide itself or from the mother's underlying condition.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual starting dose of Dulaglutide is 0.75 mg once a week. If the doctor wants better blood sugar control, the dose can be raised to 1.5 mg once a week, which is also the maximum recommended dose. Dulaglutide can be taken at any time of day, with or without food. It is injected under the skin (subcutaneously) of the abdomen, thigh or upper arm. If a dose is missed, the patient should take it as soon as possible, provided there are at least 3 days (72 hours) left before the next scheduled dose. If fewer than 3 days remain, the missed dose should be skipped and the next dose taken on the regular day. In both cases the patient then goes back to the normal once weekly schedule. The day of the week for the injection can be changed if needed, as long as the last dose was given 3 or more days earlier.