Drospirenone + Estradiol
Indications
Drospirenone + Estradiol is used as hormone replacement therapy (HRT) for climacteric syndrome in postmenopausal women. This includes vasomotor symptoms (such as hot flushes and sweating attacks), sleep disorders, depressed moods, nervousness, and atrophic urogenital conditions. These problems come from a lack of the body's own estrogen, which can be due to natural menopause, hypogonadism, castration or primary ovarian failure. The medicine is meant for women who still have their uterus. Drospirenone + Estradiol is also used to prevent postmenopausal osteoporosis.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Drospirenone and estradiol combines 173-estradiol, which is chemically and biologically identical to endogenous human E2, with the synthetic progestogen, DRSP. The 173-estradiol provides hormone replacement during and after the climacteric. DRSP helps control bleeding and opposes the endometrial hyperplasia that estrogens can cause.
Effects of estradiol: When the ovaries stop working, estrogen and progesterone production falls. This leads to the menopausal syndrome, which shows up as vasomotor and organic symptoms. Hormone replacement therapy is indicated to remove these complaints. Of all the physiological estrogens, E2 is the most potent and has the highest affinity for the estrogen receptor. The estrogen target organs include, in particular, the uterus, hypothalamus, pituitary, vagina, breast and bones (osteoclasts).
Other effects of estrogens include lower insulin and blood glucose concentrations, local vasoactive effects mediated by receptors, and receptor-independent effects on vascular smooth muscle. Estrogen receptors have been found in the heart and coronary arteries. In certain cases of hypercholesterolemia, taking natural estrogens by mouth is an advantage, because it gives the greatest beneficial metabolic effects of the liver on lipids.
Pregnancy & Breastfeeding
Ethinylestradiol & Drospirenone must not be used during pregnancy or while breastfeeding. If a woman becomes pregnant while taking Ethinylestradiol & Drospirenone, she should stop the treatment immediately. Small amounts of DRSP pass into the breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.