Community data Updated 23 hours ago

Difelikefalin Acetate

Prescription

Indications

Difelikefalin Acetate IV Infusion is used to treat moderate-to-severe pruritus (itching) linked to chronic kidney disease, known as CKD-aP, in adults who are on hemodialysis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Difelikefalin Acetate is a kappa opioid receptor agonist. Doctors use it to treat pruritus (itching) linked with chronic kidney disease in patients who are undergoing hemodialysis.

Pregnancy & Breastfeeding

There isn't much human data on Difelikefalin Acetate in pregnant women, and what exists is not enough to judge whether the medicine carries a risk of major birth defects or miscarriage. Nothing is known about whether Difelikefalin Acetate passes into human milk. There are also no data on its effects on a breastfed infant or on milk production.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The recommended dose of Difelikefalin Acetate is 0.5 mcg/kg. Administer it by intravenous bolus injection into the venous line of the dialysis circuit at the end of each hemodialysis treatment. Don't mix or dilute it before you administer it, and give it within 60 minutes of preparing the syringe. If a regularly scheduled hemodialysis treatment is missed, resume the medicine at the end of the next hemodialysis treatment. Pediatric use: the safety and effectiveness of Difelikefalin Acetate in pediatric patients have not been established. Geriatric use: no overall differences in safety or effectiveness of Difelikefalin Acetate have been observed between patients 65 years of age and older and young adult subjects.