Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Deutetrabenazine

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Indications

Deutetrabenazine is a vesicular monoamine transporter 2 (VMAT2) inhibitor. Doctors use it to treat chorea associated with Huntington's disease, and tardive dyskinesia in adults.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Nobody knows exactly how deutetrabenazine works against chorea. The belief is that it acts by reducing monoamines (dopamine, serotonin, norepinephrine and histamine) in the nerve terminals, and this effect is reversible.

Its main circulating metabolites, α-dihydrotetrabenazine and β-dihydrotetrabenazine, are reversible inhibitors of vesicular monoamine transporter 2 (VMAT2). With VMAT2 blocked, less monoamine is taken up into the synaptic vesicles, so the monoamine stores run down.

Pregnancy & Breastfeeding

There isn't enough data to say what risk deutetrabenazine may carry for the development of a baby when it is used in pregnancy. Nor is anything known about whether deutetrabenazine or its metabolites pass into human milk, what effect they might have on a breastfed infant, or whether the medicine changes how much milk a mother makes.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Patients not presently receiving Tetrabenazine Chorea associated with Huntington's disease Initial dose: 6 mg/day. Maintenance dose: 6 mg to 48 mg/day. Maximum dose: 48 mg/day. Tardive dyskinesia Initial dose: 12 mg/day. Maintenance dose: 12 mg to 48 mg/day. Maximum dose: 48 mg/day. Titrate up at weekly intervals by 6 mg per day to a tolerated dose that reduces chorea, up to a maximum recommended daily dosage of 48 mg (24 mg twice daily). Give total daily dosages of 12 mg or above in two divided doses, and give them with food. Patients receiving Tetrabenazine If you are switching a patient from tetrabenazine, stop tetrabenazine and start deutetrabenazine the following day. The recommended starting regimen for deutetrabenazine in these patients is shown in the chart below, listed as the current tetrabenazine daily dosage followed by the initial deutetrabenazine regimen: 12.5 mg gives 6 mg once daily, 25 mg gives 6 mg once daily, 37.5 mg gives 9 mg once daily, 50 mg gives 12 mg once daily, 62.5 mg gives 15 mg once daily, 75 mg gives 18 mg once daily, 87.5 mg gives 21 mg once daily, and 100 mg gives 24 mg once daily. After patients are switched to deutetrabenazine, the dose may be adjusted at weekly intervals.