Indications
Acute Bacterial Skin and Skin Structure Infections Delafloxacin is used in adults to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible microorganisms. These are Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible [MSSA] isolates), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus), Streptococcus pyogenes, Enterococcus faecalis, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Community-Acquired Bacterial Pneumonia Adults can also take delafloxacin for community-acquired bacterial pneumonia (CABP) caused by susceptible microorganisms. These are Streptococcus pneumoniae, Staphylococcus aureus (methicillin-susceptible [MSSA] isolates only), Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae, Haemophilus parainfluenzae, Chlamydia pneumoniae, Legionella pneumophila, and Mycoplasma pneumoniae.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Delafloxacin works by blocking two bacterial enzymes, DNA topoisomerase IV and DNA gyrase (also called topoisomerase II). When these enzymes are blocked, the bacteria can't copy their DNA properly. Normally, positive supercoils build up during the elongation process and have to be relaxed, and delafloxacin stops that from happening. The strain that results prevents any further elongation.
Delafloxacin kills bacteria in a concentration-dependent way, so a higher concentration gives a stronger killing effect. Animal models of infection suggest that its antibacterial activity matches best with the ratio of the area under the concentration-time curve of free delafloxacin to the minimal inhibitory concentration (fAUC/MIC). This holds for Gram-positive organisms such as Staphylococcus aureus and for Gram-negative organisms such as Escherichia coli.
Pregnancy & Breastfeeding
There isn't much data on Delafloxacin use in pregnant women, and what exists is not enough to tell whether the medicine carries a risk of major birth defects or miscarriage. For breastfeeding, nothing is known about whether Delafloxacin passes into human milk. The effects on a breast-fed infant and on milk production are also unknown.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.