Indications
Darolutamide is used to treat patients who have non-metastatic castration resistant prostate cancer.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Darolutamide is an androgen receptor (AR) inhibitor. It works in three ways: it competes with androgens for binding to the receptor, it blocks the receptor from moving into the cell nucleus, and it stops AR-mediated transcription.
Darolutamide has a major metabolite called keto-darolutamide, and in vitro this metabolite showed similar activity to Darolutamide itself. In vitro, Darolutamide also acted as a progesterone receptor (PR) antagonist, though only at approximately 1% of its activity against AR.
In laboratory studies, Darolutamide reduced the growth of prostate cancer cells in vitro. It also reduced tumor volume in mouse xenograft models of prostate cancer.
Pregnancy & Breastfeeding
Darolutamide has not been shown to be safe or effective in females. Going by how the medicine works, it can harm an unborn baby and can cause loss of pregnancy. No animal studies on embryo and fetal development were done with Darolutamide, and there are no human data on its use in pregnant females.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.