Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago

Dapoxetine Hydrochloride

Drugs for Erectile Dysfunction Prescription
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Indications

Prolong (dapoxetine hydrochloride) is used to treat premature ejaculation (PE) in men aged 18 to 64 years who have one or all of the following. Ejaculation that keeps happening, or comes back again and again, with very little sexual stimulation before, during or shortly after penetration, and sooner than the man wishes. Marked personal distress or difficulty with his partner because of PE. Poor control over ejaculation.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Dapoxetine is thought to work in premature ejaculation by blocking the reuptake of serotonin into nerve cells. This increases the action of serotonin at receptors on both sides of the nerve junction (pre- and post-synaptic). Ejaculation in humans is mainly controlled by the sympathetic nervous system. The pathway starts from a spinal reflex centre, which is mediated by the brain stem. This centre is first influenced by a number of nuclei in the brain (the medial preoptic and paraventricular nuclei).

Dapoxetine is absorbed quickly. The maximum plasma concentration (Cmax) is reached about 1 to 2 hours after taking the tablet. The absolute bioavailability is 42%. In vitro, more than 99% of dapoxetine binds to human serum proteins, and its active metabolite, desmethyl dapoxetine (DED), is 98.5% protein bound. Dapoxetine seems to distribute rapidly, with a mean steady state volume of distribution of 162 L.

The body metabolises dapoxetine extensively into multiple metabolites. The main pathways are N-oxidation, N-demethylation, naphthyl hydroxylation, glucuronidation and sulfation. There was evidence of presystemic first-pass metabolism after oral administration. The metabolites were mainly eliminated in urine as conjugates. Dapoxetine is cleared rapidly, and the terminal half life is about 19 hours.

Pregnancy & Breastfeeding

Dapoxetine Hydrochloride is not meant for use by women. Nobody knows yet whether dapoxetine or its metabolites pass into human breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: For premature ejaculation in adult men aged 18 to 64 years, the recommended starting dose of Dapoxetine is 30 mg. Take it as needed, about 1 to 3 hours before sexual activity. Don't take it more than once every 24 hours. If 30 mg doesn't work well enough and the side effects are acceptable, the dose may be raised to the maximum recommended dose of 60 mg. Dapoxetine can be taken with or without food. Children and adolescents: Dapoxetine should not be used by anyone below 18 years of age. Elderly (65 years and over): Safety and efficacy of Dapoxetine have not been established in patients aged 65 years and over, because only limited data are available for this group. Patients with renal impairment: Take care in patients with mild or moderate renal impairment. Dapoxetine is not recommended for patients with severe renal impairment. Patients with hepatic impairment: Dapoxetine is contraindicated in patients with moderate and severe hepatic impairment.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.