Indications
Colistimethate Sodium is used to treat acute or chronic infections caused by sensitive strains of certain gram-negative bacilli. It is particularly indicated for infection caused by sensitive strains of Pseudomonas aeruginosa. It is not indicated for infections due to Proteus or Neisseria. Colistimethate Sodium works very well against infections caused by these gram-negative organisms: Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Colistimethate is a surface active agent. It penetrates the bacterial cell membrane and disrupts it. The molecule is polycationic and has both hydrophobic and lipophilic moieties, and it interacts with the bacterial cytoplasmic membrane and changes its permeability. This action is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, mainly the ribosomes.
Pregnancy & Breastfeeding
No adequate and well-controlled studies have looked at the use of Colistimethate in pregnant women. Colistimethate crosses the placental barrier in humans, so it should be used during pregnancy only if the likely benefit justifies the possible risk to the fetus. It isn't known whether Colistimethate passes into human breast milk. For that reason, take care when giving it to nursing women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.