Indications
Cilnidipine is used to manage hypertension and to protect the organs that high blood pressure can damage (end-organ protection). It is reported to be useful in elderly patients and in those with diabetes and albuminuria. It has also been used more and more in patients with chronic kidney disease. Cilma is indicated for the same purposes and is reported to be useful in the same groups of patients. Hypertension is the term for high blood pressure. Blood pressure comes from the force of blood pumped by the heart against the blood vessels. When there is too much pressure on the vessels, that is hypertension, and it can damage them.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Cilnidipine is a dihydropyridine calcium-channel blocker. It binds to the dihydropyridine binding sites of the L-type voltage dependent calcium channel and blocks Ca2+ from entering the vascular smooth muscle cells through that channel. The smooth muscle relaxes as a result, and this causes vasodilation.
Cilnidipine also blocks Ca2+ entry through N-type voltage dependent calcium channels in the membrane of sympathetic nerve cells. This block on the N-type channel was seen at drug concentrations similar to those that inhibit the L-type channels. So the release of norepinephrine from the sympathetic nerve terminals would be inhibited. Cilnidipine is considered to suppress the reflex rise in heart rate that follows a fall in blood pressure.
Pregnancy & Breastfeeding
Cilnidipine should not be given to a pregnant woman, or to a woman who may be pregnant. It's also best to avoid giving Cilnidipine to a nursing mother. If the medicine can't be avoided, the mother should be told to stop breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.