Indications
Cetrorelix Acetate, which is also sold as Cetrotide, is used to treat infertility in women. It stops eggs from being released too early, so it prevents premature ovulation. In female infertility, Cetrorelix Acetate holds back that early release of eggs during ovulation. This lets an egg develop normally in the woman's ovary (the female reproductive organ) and helps a healthy, matured egg to be released. In this way it helps treat infertility and increases the chance of a successful pregnancy.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Cetrorelix Acetate is a synthetic decapeptide that works against gonadotropin-releasing hormone (GnRH), so it blocks what GnRH does in the body. GnRH controls the secretion of luteinizing hormone (LH), and LH is what brings on ovulation during the menstrual cycle. In hormone treatment for ovarian stimulation, ovulation that happens too early may leave eggs that are not suitable for fertilization. Cetrorelix Acetate blocks this unwanted early ovulation.
GnRH causes the gonadotropic cells of the anterior pituitary to produce and release luteinizing hormone (LH) and follicle stimulating hormone (FSH). At midcycle, a positive estradiol (E2) feedback increases the liberation of GnRH, and this results in an LH-surge. The surge induces ovulation of the dominant follicle, resumption of oocyte meiosis and then luteinization, which shows as rising progesterone levels.
Cetrorelix Acetate competes with natural GnRH for binding to membrane receptors on pituitary cells. In this way it controls the release of LH and FSH in a dose-dependent manner. With the 0.25 mg dose, LH suppression starts in approximately two hours. Continuous treatment maintains the suppression, and the effect on LH is more pronounced than the effect on FSH. No initial release of endogenous gonadotropins has been detected with Cetrorelix injection, which is consistent with an antagonist effect. The effects on LH and FSH are reversible after treatment is stopped.
In women, Cetrorelix Acetate delays the LH-surge, and so ovulation, in a dose dependent fashion. FSH levels are not affected at the doses used during controlled ovarian stimulation. A dose of Cetrorelix Acetate 0.25 mg every 24 hours has been shown to maintain the effect.
Pregnancy & Breastfeeding
Cetrorelix Acetate should not be used during pregnancy or while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.