Indications
Ceframax is used to treat infections caused by sensitive Gram-positive and Gram-negative bacteria. These include the following. Upper respiratory tract infections: sinusitis, pharyngitis, tonsillitis, laryngo-tracheo bronchitis and otitis media. Lower respiratory tract infections: bronchitis (acute and chronic), lobar pneumonia and bronchopneumonia. Urinary tract infections: cystitis, urethritis and pyelonephritis. Skin and soft tissue infections: abscess, cellulitis, furunculosis and impetigo. In vitro, the following microorganisms are susceptible to Ceframax. Among the Gram-positive ones are Staphylococci (both penicillin sensitive and resistant strains, including penicillinase-producing species), Streptococci, Streptococci pyogenes (beta haemolytic) and Streptococcus pneumonia. The Gram-negative ones are Escherichia coli, Klebsiella spp, Proteus mirabilis, Haemophilus influenza, Shigella spp, Salmonella spp (including Salmonella typhi) and Neisseria spp. Many strains of E.coli and Staphylococcus aureus produce the enzyme penicillinase, which makes them resistant to ampicillin. Ceframax is not affected by this enzyme, so these strains are still susceptible to it.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Cephradine is a semisynthetic, broad-spectrum bactericidal antibiotic that works against both gram-positive and gram-negative organisms. It is effective against staphylococci whether or not they produce penicillinase. Cephradine acts mainly on the bacterial cell wall, which is built from peptidoglycan in susceptible organisms. By blocking the cross-linking of peptidoglycan strands, it leaves the cell wall riddled with gaps; the resulting external osmotic pressure then causes the bacterial cell to burst.
Pregnancy & Breastfeeding
Although animal studies have shown no evidence of teratogenicity, cephradine's safety in pregnancy has not been firmly established. The medicine does pass into breast milk, so it should be used cautiously by breastfeeding mothers. It can also cause dizziness in some patients, so anyone taking it should be careful when driving or operating heavy machinery.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.