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Cefixime Trihydrate

Third generation cephalosporins Prescription
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Indications

Pneumonia Bronchitis Urinary Tract Infection Respiratory Tract Infection Otitis Media

Cefixime Trihydrate is a cephalosporin antibiotic that you take by mouth. In the laboratory it shows marked bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms. It is indicated for the treatment of the following acute infections when they are caused by susceptible microorganisms. Upper Respiratory Tract Infections (URTI): for example otitis media, and other URTI where the causative organism is known or suspected to be resistant to other commonly used antibiotics, or where treatment failure may carry significant risk. Lower Respiratory Tract Infections: for example bronchitis. Urinary Tract Infections: for example cystitis, cystourethritis and pyelonephritis. Clinical efficacy has been demonstrated in infections caused by commonly occurring pathogens. These include Streptococcus pneumonia, Streptococcus pyogenes, Escherichia coli, Proteus mirabilis, Klebsiella species, Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative) and Enterobacter species. Cefixime Trihydrate is also highly stable in the presence of beta-lactamase enzymes.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Cefixime is a third generation semisynthetic cephalosporin antibiotic that you take by mouth. It is bactericidal, which means it kills bacteria, and it works against a broad spectrum of gram positive and gram negative bacteria at plasma concentrations that are easily achieved. It does this by interfering with the synthesis of the bacterial cell wall.

Cefixime is highly stable in the presence of the Beta-lactamase enzyme. Because of this, many organisms that resist penicillins and some cephalosporins through beta-lactamases may still be susceptible to Cefixime. About 40% to 50% of the medicine is absorbed, and this is the same whether you take it with or without food.

Pregnancy & Breastfeeding

There are no adequate and well-controlled studies of Cefixime in pregnant women. Animal reproduction studies don't always predict how a human will respond, so the medicine should be used during pregnancy only if it is clearly needed. It is not known whether Cefixime passes into human milk. For that reason, take care when giving Cefixime to a nursing woman.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Food doesn't change how well Cefixime is absorbed. The usual course is 7 days, and it can be continued for up to 14 days if required. Adults and children over 10 years: The recommended adult dose is 200 to 400 mg daily, depending on how severe the infection is. It can be given as a single dose or as two divided doses. Elderly: Elderly patients may be given the same dose as adults. Renal function should be assessed, and the dose should be adjusted in severe renal impairment. Children: The recommended dose is 8 mg/kg/day, given as a single dose or in two divided doses. As a general guide, these daily doses are suggested in terms of volume of suspension: 6 months up to 1 year: 3.75 ml daily Children 1 to 4 years: 5 ml daily Children 5 to 10 years: 10 ml daily In typhoid, the recommended dose for children is 5 mg/kg body weight twice daily for 10 to 14 days. Children weighing more than 50 kg or older than 10 years should be treated with the adult dose of 200 to 400 mg daily, depending on the severity of the infection. For children aged less than 6 months, the safety and efficacy of Cefixime have not been established. Dosage in renal impairment: Cefixime may be given when kidney function is impaired. The normal dose and schedule can be used in patients with creatinine clearance of 20 ml/min or greater. If creatinine clearance is less than 20 ml/min, a dose of 200 mg once daily should not be exceeded. Patients maintained on chronic ambulatory peritoneal dialysis or haemodialysis should follow the same recommendation as those with creatinine clearance of less than 20 ml/min.