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Canagliflozin Hemihydrate

Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors Prescription

Indications

Type 2 Diabetes Mellitus Diabetes Mellitus

Canagliflozin Hemihydrate is used along with diet and exercise to help improve blood sugar control in adults with type 2 diabetes mellitus.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Canagliflozin works by blocking SGLT2, the subtype-2 sodium-glucose co-transport protein. This protein is responsible for at least 90% of the glucose reabsorption in the kidney. When canagliflozin blocks it, less glucose is taken back up from the renal tubules, so more glucose leaves the body in the urine.

Pregnancy & Breastfeeding

Canagliflozin Hemihydrate is Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women, so use it during pregnancy only if the potential benefit justifies the potential risk to the fetus. A nursing mother should either stop the medicine or stop nursing.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The usual starting dose of Canagliflozin is 100 mg once daily, taken before the first meal of the day. The dose can be raised to 300 mg once daily for people with CrCl>60 ml/min, or for those who need additional glycemic control. Mild renal impairment needs no dose adjustment. In moderate renal impairment (CrCl 45-60 ml/min), Canagliflozin 100 mg is recommended.

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Canagliflozin Hemihydrate

Indications

Pharmacology

Pregnancy & Breastfeeding

Dosage Reference

Side Effects & Interactions

Side Effects

Key Interactions