Calcium Citrate + Calcitriol

Calcium, one of the two components of Calcium Citrate + Calcitriol, plays a very important role in the body. It is necessary for the normal working of nerves, cells, muscle and bone. If there isn't enough calcium in the blood, the body takes calcium from the bones, and this weakens them. Having the right amount of calcium is important for building and keeping strong bones. Calcium citrate is well absorbed on an empty stomach and does not cause constipation. It also depends less on stomach acid for absorption.

Calcitriol is the most active known form of vitamin D 3 in stimulating intestinal calcium transport. The body normally forms it in the kidneys from its immediate precursor, 25-hydroxycholecalciferol. In physiological amounts it increases the intestinal absorption of calcium and phosphate, and it plays a significant part in regulating bone mineralization. In chronic renal failure, the body doesn't produce calcitriol properly, and this contributes to the abnormalities of mineral metabolism seen in that disorder. The biological effects of calcitriol are mediated by the vitamin D receptor. This is a nuclear hormone receptor found in most cell types, and it works as a ligand-activated transcription factor that binds to DNA sites and changes the expression of target genes.

When Calcitriol is given by mouth to patients with chronic renal failure, it makes up for the impaired endogenous production of calcitriol, which is decreased when the glomerular filtration rate falls below 30 ml/min. As a result, the intestinal malabsorption of calcium and phosphate and the hypocalcemia that follows are improved, and the signs and symptoms of bone disease are reversed. In patients with established post-menopausal osteoporosis, Calcitriol increases calcium absorption, raises circulating levels of calcitriol and reduces the frequency of vertebral fractures.