Bupivacaine Hydrochloride + Dextrose

Indications

Bupivacaine Hydrochloride + Dextrose intraspinal injection is used for lower abdominal surgery (including Caesarean section), urological and lower limb surgery, including hip surgery, lasting 1.5 to 3 hours. It is given as intrathecal (subarachnoid, spinal) anesthesia for surgical and obstetrical procedures. Vaspine intraspinal injection is indicated for the same uses: lower abdominal surgery (including Caesarean section), urological and lower limb, including hip surgery, lasting 1.5 to 3 hours, and intrathecal (subarachnoid, spinal) anesthesia for surgical and obstetrical procedures. Bupivacaine Hydrochloride + Dextrose produces motor blockade of the abdominal muscles, and this makes the solution suitable for abdominal surgery lasting 1.5 to 2 hours. The motor blockade does not last longer than the analgesia.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Bupivacaine is a long acting local anesthetic of the amide type. Bupivacaine spinal 5 mg/ml is a sterile solution that contains no glucose. It starts working quickly, and the analgesia lasts 3 to 5 hours in the lower thoracic and lumbar segments. That makes Bupivacaine spinal especially suitable for long procedures on the lower limbs.

The muscle relaxation in the lower limbs is profound. It lasts 3 to 4 hours, which is somewhat shorter than the sensory blockade. The effects on the circulation are similar to those of other spinal agents, or less. Every tissue it comes in contact with tolerates it well.

Pregnancy & Breastfeeding

It's reasonable to assume that a large number of pregnant women, and women of child-bearing age, have been given Bupivacaine. No specific disturbances to the reproductive process have been reported so far, for example no increased incidence of malformations. The dose should be reduced in patients in the late stages of pregnancy. At the recommended doses, Bupivacaine enters breast milk in such small quantities that there is generally no risk of affecting the breast-fed child. When epidural use for vaginal delivery produced maternal serum levels of up to 0.45 g/mL, none could be detected in breast milk during the first 24 hours after delivery (detection limit 0.02 g/mL).

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: The following doses are a guide for the average adult. For spinal anaesthesia for surgery, the dose of Bupivacaine Hydrochloride with dextrose is 2 to 4 ml (10 to 20 mg Bupivacaine hydrochloride). The patient's physical status and any other medicine they are taking should be considered when the dose is decided, and the lowest dose that gives adequate anaesthesia should be used. Duration varies with the dose. The segmental spread can be hard to predict, especially with the isobaric (plain) solution. The dose should be reduced in the elderly and in patients in the late stages of pregnancy. Pediatrics Bupivacaine may be used in children. Infants and neonates have a relatively high CSF volume compared with adults, so they need a relatively larger dose per kg to reach the same level of block. The doses are 0.40 to 0.50 mg/kg for children under 5 kg, 0.30 to 0.40 mg/kg for 5 to 15 kg, and 0.25 to 0.30 mg/kg for 15 to 40 kg.

Side Effects & Interactions

Side Effects

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