Indications
Bromocriptine Mesylate is used for dysfunctions associated with hyperprolactinemia, including amenorrhea with or without galactorrhea, infertility or hypogonadism. For prolactin secreting adenomas, when adenectomy is elected, a course of bromocriptine mesilate therapy may be used to reduce the tumor mass before surgery. It is also listed for acromegaly. In Parkinson's disease, it is used for idiopathic or postencephalitic Parkinson's disease, as adjunctive treatment to levodopa (alone or with a peripheral decarboxylase inhibitor).
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Bromocriptine mesilate is a nonhormonal, nonestrogenic agent that inhibits the secretion of prolactin in humans. It has little or no effect on other pituitary hormones, except in patients with acromegaly, where it lowers elevated blood levels of growth hormone. The medicine is a dopamine receptor agonist, so it activates post-synaptic dopamine receptors.
Dopaminergic neurons in the tuberoinfundibular process modulate the secretion of prolactin from the anterior pituitary by secreting a prolactin inhibitory factor (thought to be dopamine). Dopaminergic neurons in the corpus striatum are involved in the control of motor function. Clinically, bromocriptine significantly reduces plasma levels of prolactin, both in patients with physiologically elevated prolactin and in patients with hyperprolactinemia.
Pregnancy & Breastfeeding
Bromocriptine is in pregnancy category B. Postpartum women should not use it while they are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.