Brivaracetam

Adults: Brivaracetam tablet or oral solution is taken by mouth, with or without food. The recommended dose for patients 1 month of age and older is given below. In pediatric patients weighing less than 50 kg, the dosing depends on body weight. You don't need to build the dose up gradually when starting treatment. Adjust it according to clinical response and how well the patient tolerates it. Adults (16 years and older): the initial dose is 50 mg twice daily (100 mg per day). The minimum and maximum maintenance dose is 25 mg to 100 mg twice daily (50 mg to 200 mg per day). Pediatric patients weighing 50 kg or more: the initial dose is 25 mg to 50 mg twice daily (50 mg to 100 mg per day). The minimum and maximum maintenance dose is 25 mg to 100 mg twice daily (50 mg to 200 mg per day). Pediatric patients weighing 20 kg to less than 50 kg: the initial dose is 0.5 mg/kg to 1 mg/kg twice daily (1 mg/kg to 2 mg/kg per day). The minimum and maximum maintenance dose is 0.5 mg/kg to 2 mg/kg twice daily (1 mg/kg to 4 mg/kg per day). Pediatric patients weighing 11 kg to less than 20 kg: the initial dose is 0.5 mg/kg to 1.25 mg/kg twice daily (1 mg/kg to 2.5 mg/kg per day). The minimum and maximum maintenance dose is 0.5 mg/kg to 2.5 mg/kg twice daily (1 mg/kg to 5 mg/kg per day). Pediatric patients weighing less than 11 kg: the initial dose is 0.75 mg/kg to 1.5 mg/kg twice daily (1.5 mg/kg to 3 mg/kg per day). The minimum and maximum maintenance dose is 0.75 mg/kg to 3 mg/kg twice daily (1.5 mg/kg to 6 mg/kg per day). Geriatric use: choose the dose for an elderly patient with care, usually starting at the low end of the dosing range. Renal impairment: patients with impaired renal function don't need a dose adjustment. Brivaracetam is not recommended in patients with end stage renal disease who are undergoing dialysis. Use in children and adolescents: safety and effectiveness have not been established in pediatric patients below the age of 1 month.