Indications
Brexpiprazole is an atypical antipsychotic. It is used as an add-on treatment alongside antidepressants for major depressive disorder (MDD), and it is also used to treat schizophrenia.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Brexpiprazole is an atypical antipsychotic. Its effects are believed to come from how it modulates the serotonin and dopamine systems. It works as a partial agonist at serotonergic 5-HT1A receptors and at dopaminergic D2 receptors, and as an antagonist at serotonergic 5-HT2A receptors. Its affinity is similarly high at all of these receptors. Brexpiprazole also acts as an antagonist at noradrenergic a1B/2c receptors.
Pregnancy & Breastfeeding
There is a pregnancy exposure registry that follows pregnancy outcomes in women who were exposed to Brexpiprazole while pregnant. No lactation studies have been done, so we don't know whether brexpiprazole passes into human milk, what it does to a breastfed infant, or whether it changes milk production. It is present in rat milk. When deciding about breastfeeding, the mother's clinical need for Brexpiprazole should be weighed together with the development and health benefits of breastfeeding. Any possible adverse effects on the breastfed infant, whether from the medicine or from the mother's underlying condition, should also be considered.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.