Indications
Bilastine is used for the symptomatic treatment of allergic rhino conjunctivitis (both seasonal and perennial) and urticaria. It is also used to relieve the symptoms of hay fever, which include sneezing, an itchy, runny or blocked nose, and red, watery eyes.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Bilastine is a potent, long-acting histamine antagonist that doesn't cause sedation. It binds selectively and strongly to the H1 receptor, 3 times more strongly than Cetirizine and 5 times more strongly than Fexofenadine. Even at a high concentration, Bilastine shows no affinity for 30 other receptors, including the muscarinic, serotonergic, dopaminergic and noradrenergic receptors. It also doesn't bind to the other histamine receptor subtypes (H2, H3 and H4).
The safety profile is excellent, and the pharmacokinetic characteristics are very favourable. Bilastine doesn't need to be metabolised to become active. It leaves the body through feces (non-systemic) and urine (systemic), at approximately 66.35% and 28.31% respectively.
Pregnancy & Breastfeeding
There is little or no data on the use of Bilastine in pregnant women. Animal studies don't show any direct or indirect harmful effects on reproductive toxicity, parturition or postnatal development. Even so, as a precaution, it is better to avoid Bilastine during pregnancy.
Whether Bilastine passes into breast milk has not been studied in humans. So the decision needs to weigh the benefit of breast-feeding for the child against the benefit of Bilastine therapy for the mother.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.