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Betamethasone Dipropionate

Corticosteroid Prescription
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Indications

Betamethasone Dipropionate cream and ointment is used to relieve the inflammation and itching of resistant or severe corticosteroid-responsive dermatoses. These include atopic eczema, nummular eczema, contact dermatitis, neurodermatitis, anogenital and senile pruritus, lichen planus and psoriasis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Betamethasone Dipropionate is a topical corticosteroid. It reduces inflammation, relieves itching and narrows the blood vessels. The medicine induces peptides called lipocortins, and these lipocortins antagonize phospholipase A2. This enzyme breaks down the membranes of leukocyte lysosomes and so releases arachidonic acid. When phospholipase A2 is blocked, the body forms and releases fewer of the inflammatory mediators that follow, including prostaglandins, kinins and histamine.

Pharmacokinetics: Betamethasone Dipropionate can be absorbed through normal intact skin. Corticosteroids bind to plasma proteins in varying degrees. They are metabolized mainly in the liver and excreted by the kidneys.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Apply a thin film of Betamethasone Dipropionate once or twice a day, enough to cover the affected area completely. Some people with chronic psoriasis improve a great deal, at least a marked improvement in the lesion (about 80% improvement). These patients can be kept in remission with a pulse dosing regimen. It means three applications in a row, each of up to 3.5 g of Betamethasone Dipropionate cream and ointment, twelve hours apart (for example morning, evening, then the next morning). The medicine goes on the areas that were affected before, once each week. For this purpose, the cream and ointment should be put on the lesion sites that were previously affected and treated. If a patient on the pulse regimen relapses, they should go back to the conventional dosing regimen.