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Community data Updated 23 hours ago

Azelastine Hydrochloride

Nasal Anti-histamine preparations Prescription
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Indications

Azelast nasal spray is an H1-receptor antagonist. It is used to treat the symptoms of seasonal allergic rhinitis in adults and in children aged 5 years and older. It is also used to treat the symptoms of vasomotor rhinitis in adults and adolescents aged 12 years and older. Azelast eye drop is used to treat and prevent the symptoms of seasonal allergic conjunctivitis in adults and children aged 4 years and older. It is also used to treat the symptoms of non-seasonal (perennial) allergic conjunctivitis in adults and children aged 12 years and older.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Azelastine eye drops contain the active substance azelastine hydrochloride, which belongs to a group of medicines called antiallergics (antihistamines). Antihistamines work by blocking the effects of substances such as histamine, which the body produces as part of an allergic reaction. Azelastine has been shown to reduce inflammation of the eye.

Azelastine is a phthalazinone derivative. It is classified as a potent, long-acting anti-allergic compound with selective H1 antagonist properties. An additional anti-inflammatory effect could be detected after topical ocular administration. Data from in vivo (pre-clinical) and in vitro studies show that azelastine inhibits the synthesis or release of the chemical mediators known to be involved in early and late stage allergic reactions, e.g. leukotriene, histamine, PAF and serotonin.

Pregnancy & Breastfeeding

Azelastine hasn't been studied well enough in pregnant women, so its effects during pregnancy are not clearly known. A doctor should give Azelastine in pregnancy only if the possible benefit to the mother justifies the possible risk to the baby. Nobody knows yet whether Azelastine passes into human breast milk. Even so, a nursing mother should use it with caution.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Nasal Spray, Seasonal Allergic Rhinitis For adults and adolescents 12 years and older with seasonal allergic rhinitis, the recommended dose of Azelastine Nasal Spray is one or two sprays per nostril twice daily. For children aged 5 years to 11 years, it is one spray per nostril twice daily. Vasomotor Rhinitis Adults and adolescents 12 years and older with vasomotor rhinitis should use two sprays per nostril twice daily. Azelastine Nasal Spray is for the intranasal route only. Priming Before the first use, prime the spray by releasing 4 sprays or until a fine mist appears. If the spray has not been used for 3 or more days, reprime it with 2 sprays or until a fine mist appears. Avoid spraying it into the eyes. Eye Drops, Seasonal Allergic Conjunctivitis The usual dose for adults and children 4 years and older is one drop in each eye twice daily. This can be increased to four times daily if necessary. If you expect to be exposed to an allergen, Azelastine hydrochloride Eye drops, solution should be given beforehand as a preventive measure. Non-seasonal (Perennial) Allergic Conjunctivitis For adults and children 12 years and older, the usual dose is one drop in each eye twice daily, and this can be increased to four times daily if necessary. Safety and efficacy have been shown in clinical trials for up to 6 weeks, so any course should be limited to a maximum of 6 weeks. Patients should be advised to contact their doctor if symptoms get worse or do not improve after 48 hours.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.