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Avelumab

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Indications

Cancer

Metastatic Merkel cell carcinoma: avelumab is used to treat adults and children aged 12 years and older who have metastatic Merkel cell carcinoma (MCC). Locally advanced or metastatic urothelial carcinoma, first-line maintenance treatment: avelumab is given as maintenance treatment to patients with locally advanced or metastatic urothelial carcinoma (UC) whose disease has not progressed after first-line chemotherapy that contains platinum. Metastatic Merkel cell carcinoma: the medicine is indicated for adults and children aged 12 years and older with metastatic Merkel cell carcinoma (MCC). Locally advanced or metastatic urothelial carcinoma, first-line maintenance treatment: avelumab is indicated as maintenance treatment for patients with locally advanced or metastatic urothelial carcinoma (UC) that has not progressed with first-line platinum-containing chemotherapy. Previously treated urothelial carcinoma: avelumab is indicated for patients with locally advanced or metastatic urothelial carcinoma (UC) who have disease progression during or following platinum-containing chemotherapy. It is also indicated for those whose disease has progressed within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. Advanced renal cell carcinoma: avelumab is used together with axitinib as first-line treatment for patients with advanced renal cell carcinoma (RCC).

⚠️ Always consult a registered physician before taking any medicine.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Premedication Give the patient an antihistamine and acetaminophen before each of the first 4 infusions of Avelumab. For later doses, premedication depends on clinical judgment and on whether the patient had infusion reactions before, and how severe they were. Recommended dosage for MCC The dose of Avelumab is 800 mg as an intravenous infusion over 60 minutes, given every 2 weeks. Treatment continues until the disease progresses or toxicity becomes unacceptable. Recommended dosage for UC The dose is the same as for MCC: 800 mg of Avelumab as an intravenous infusion over 60 minutes every 2 weeks, until disease progression or unacceptable toxicity. Recommended dosage for RCC Avelumab is given at 800 mg as an intravenous infusion over 60 minutes every 2 weeks, together with axitinib 5 mg taken by mouth twice daily (12 hours apart), with or without food. This continues until disease progression or unacceptable toxicity. When axitinib is used with Avelumab, the axitinib dose may be raised above the starting 5 mg, at intervals of two weeks or longer.