Indications
Apalutamide is an androgen receptor inhibitor, used to treat patients with metastatic castration-sensitive prostate cancer, non-metastatic castration-resistant prostate cancer.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Apalutamide is a tablet taken by mouth, and it works as a selective inhibitor of the Androgen Receptor (AR). It binds directly to the ligand-binding domain of the AR. This stops the AR from moving into the cell nucleus, blocks it from binding to DNA, and impedes AR-mediated transcription. Apalutamide has no androgen receptor agonist activity. With treatment, tumor cells multiply less and apoptosis increases, which gives the medicine its potent antitumor activity.
Pregnancy & Breastfeeding
Pregnancy: Apalutamide must not be used by women who are pregnant or who may become pregnant. Going by how the medicine works, it may harm the foetus if given during pregnancy. There are no data on its use in pregnant women, and animal reproductive studies have not been done.
Breast-feeding: It isn't known whether apalutamide or its metabolites pass into human milk. A risk to the suckling child can't be ruled out, so the medicine should not be used during breast-feeding.
Females and Males of Reproductive Potential: Contraception in males and females: It is not known whether apalutamide or its metabolites are present in semen. The medicine may be harmful to a developing foetus. Patients having sex with female partners of reproductive potential should use a condom along with another highly effective contraceptive method during treatment and for 3 months after the last dose.
Fertility: Animal studies suggest that apalutamide may decrease fertility in males of reproductive potential.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.