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Amlodipine Besilate + Telmisartan

Combined antihypertensive preparations Prescription
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Indications

Hypertension

Amlodipine Besilate + Telmisartan is used to treat hypertension (high blood pressure). Doctors can prescribe it on its own or together with other antihypertensive medicines. It can also be the first treatment for patients who are likely to need more than one drug to reach their blood pressure goals.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

This medicine is a fixed dose combination of Telmisartan and Amiodipine. Telmisartan is a non-peptide angiotensin receptor blocker (ARB). It is a specific angiotensin II antagonist and acts on the AT1 subtype. Angiotensin II is the principal pressor agent of the renin-angiotensin system. Its effects include vasoconstriction, stimulation of the synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium, and together these lead to a rise in blood pressure (hypertension). Telmisartan selectively blocks angiotensin II from binding to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. This blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II. So Telmisartan dilates blood vessels and lowers blood pressure without affecting pulse rate. Its affinity for the AT1 receptor is much greater (>3,000 fold) than for the AT2 receptor, and it does not bind or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Amiodipine is a dihydropyridine calcium-channel blocker (CCB). It inhibits the transmembrane influx of calcium ion into vascular smooth muscle and cardiac muscle. Amiodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle, which reduces peripheral vascular resistance and lowers blood pressure.

Pregnancy & Breastfeeding

Pregnancy Categories C apply in the first trimester and D in the second and third trimesters. Nobody knows yet whether telmisartan and amiodipine pass into human breast milk. Because the nursing infant could be harmed, either stop nursing or stop the drug, after weighing how important the drug is to the mother.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Initial therapy: Amlodipine Besilate + Telmisartan tablets can be started in a patient when a single medicine is unlikely to bring blood pressure under control. The usual starting dose is 40/5 mg once daily. Patients who need a larger fall in blood pressure may start with 80/5 mg once daily. Starting treatment with this combination is not recommended in patients 575 years old or in those with hepatic impairment. Add-on therapy: This applies to patients whose blood pressure is not adequately controlled with amlodipine (or another dihydropyridine calcium channel blocker) alone, or with telmisartan (or another angiotensin receptor blocker) alone. Patients taking 10 mg amlodipine who get adverse reactions such as edema may be switched to the 40/5 mg tablet once daily. This lowers the amlodipine dose without reducing the overall expected antihypertensive response. Replacement therapy: Patients who take amlodipine and telmisartan as separate tablets can instead take a single tablet containing the same component doses once daily. The dose must be set for each patient and may be increased after at least 2 weeks. The maximum recommended dose of Amlodipine Besilate + Telmisartan is 80/10 mg once daily.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.