Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 23 hours ago
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Indications

Amisulpride is used to treat acute and chronic schizophrenic disorders. It suits people whose illness is marked by positive symptoms, such as delusions, hallucinations and thought disorders, and also those with negative symptoms, such as blunted affect and emotional and social withdrawal. It can be used as well for patients in whom negative symptoms are the main problem.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Amisulpride belongs to a group of medicines called antipsychotics, which help control the symptoms of a mental illness called schizophrenia. It binds selectively to the human dopaminergic D2 and D3 receptors, and it has no affinity for all, D4 and D5 receptor subtypes. Classical and atypical neuroleptics behave differently here, because amisulpride shows low affinity for serotonin, a-adrenergic and histamine receptor subtypes, as well as muscarinic receptors and sigma sites. It does not induce catalepsy, and repeated treatment does not produce D2 hypersensitivity. It also blocks pre-synaptic D2/D3 dopamine receptors in preference to others, which produces dopamine release, and this is responsible for its disinhibitory effects.

Pregnancy & Breastfeeding

Nobody has established that amisulpride is safe during human pregnancy, so it isn't recommended in pregnancy. The same applies to women who could become pregnant and are not using effective contraception. The exception is when the benefits justify the possible risks, and in that case the dose and the length of treatment should be kept as low and as short as possible.

Amisulpride has been found in the breast milk of women who are treated with it. Breast-feeding is contraindicated.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Oral dose: For acute psychotic episodes, Amisulpride is recommended at 400 mg/day to 800 mg/day in individual cases. The daily dose can be raised up to 1200 mg/day. Doses above 800 mg/day have not been shown to work better than lower doses, and they may increase the number of adverse events. You don't need a specific titration when starting Amisulpride. Adjust the dose according to how each patient responds, and give it preferably before a meal. For patients with mixed positive and negative symptoms, adjust the dose to get the best control of the positive symptoms. Maintenance treatment should be set individually, using the lowest dose that works. For patients whose symptoms are mainly negative, oral doses of 50 mg/day to 300 mg/day are recommended, again adjusted for each person. Injectable dose: The recommended adult injectable dose and infusion rate for each indication are given below. Prevention of postoperative nausea and vomiting: 5 mg as a single intravenous injection, infused over 1 to 2 minutes at the time of induction of anesthesia. Treatment of postoperative nausea and vomiting: 10 mg as a single intravenous injection, infused over 1 to 2 minutes, if nausea and/or vomiting occurs after a surgical procedure.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.