Indications
Aloglip is used together with diet and exercise to help control blood sugar in adults with type-2 diabetes mellitus.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Alogliptin is a DPP-4 inhibitor. It slows down the breakdown of the incretin hormones, so their levels in the blood go up. In people with type 2 diabetes mellitus, this lowers both fasting and after-meal glucose, and it does so only in a glucose-dependent way.
The incretin hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The small intestine releases them into the bloodstream in response to meals. They make the pancreatic beta cells release insulin, again depending on glucose levels, but the DPP-4 enzyme inactivates them within minutes. GLP-1 also lowers glucagon secretion from the pancreatic alpha cells, and this reduces the glucose the liver produces. In patients with type 2 diabetes, GLP-1 concentrations are reduced, but the insulin response to GLP-1 is preserved.
Pregnancy & Breastfeeding
Alogliptin is Pregnancy Category B. No adequate or well-controlled studies have been done in pregnant women, so Alogliptin tablets should be used in pregnancy only if clearly needed.
It isn't known whether Alogliptintin is excreted in human milk. Caution should be exercised when Alogliptin is given to a nursing woman.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.