Allium cepa + Heparin + Allantoin

Allium cepa extract comes from the membrane of the onion (Allium cepa). It has an antiphlogistic effect because it inhibits the secretion of inflammatory mediators, and it also has an anti-allergenic effect. The extract inhibits the growth of fibroblasts of different origin, particularly keloidal fibroblasts. It is bactericidal too. These properties stimulate primary wound healing, and the extract prevents non-physiological scar formation.

Heparin

When applied locally, heparin inhibits fibroblast proliferation. It increases tissue hydration and reduces the irritation that results from induration and inflammation.

Allantoin

Allantoin stimulates cellular proliferation and supports the development of healthy cells. It is a suitable substance for treating scars, because it stimulates epithelization and helps form an elastic surface.

Clinical studies

One study evaluated Allium cepa extract, Heparin and Allantoin gel for preventing scar formation. A total of 1,268 patients were evaluated. After 2 to 3 months of treatment with the gel, mean scar width was reduced by 31.5% and mean scar height by 47.8% at the end of the observation period.

Another study assessed Allium cepa extract, Allantoin and Heparin in the early treatment of C-section scars. A total of 61 females, aged ≥18 years, who had given birth by C-section were evaluated. After six weeks of treatment, the gel showed significant improvement in the color, stiffness and irregularity of the scars.