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All price changes →Zuracin
Rx125 mg/5 ml • Powder For Suspension
Indications & Uses
Pharmacology
Erythromycin stops protein synthesis in susceptible organisms by blocking the translocation process. It binds specifically to the 50S subunit or 70S ribosome in these organisms, but it does not bind to the stable 80S mammalian ribosome. It is active against many Grampositive bacteria, some Gram-negative bacteria, and against mycoplasmas and chlamydia.
Absorption: Acid destroys erythromycin base, so it is given as a stable ester. Food slows the absorption of both the base and the esters. The stearate is hydrolyzed in the intestine and the free erythromycin is then absorbed.
Blood concentration: After an oral dose of 500 mg of the base or the stearate, peak serum concentrations of 0.9 to 1.4 mg/ml or 0.4 to 1.8 mg/ml respectively are reached in 1 to 4 hours.
Half-life: The serum half-life is 1.2 to 4 hours. In people with oliguria it is about 5 hours.
Distribution: Erythromycin spreads widely through body tissues and fluids, with some retention in the liver and spleen. Protein binding of erythromycin base is 73%. It enters the cerebrospinal fluid when the meninges are inflamed. It also crosses the placenta and is excreted in milk.
Excretion: 5 to 15% of the dose is excreted in the urine, and large amounts of the unchanged active substance are excreted in the bile.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and children over 8 years: 250 to 500 mg every six hours for mild to moderate infections. In severe cases, this may be increased to up to 4 gm or more daily.
Elderly: No special dosage recommendation is needed. Erythromycin may be given, if desired, three times daily or twice daily, using one third or half of the total daily dose every 8 hours or every 12 hours respectively.
Children aged 2 to 8 years: 250 mg every six hours, or 30 to 50 mg per kg body weight per day divided into four equal doses.
Infants and children up to 2 years: 500 mg in divided doses, or 30 to 50 mg per kg body weight in divided doses.
Side Effects
Allergic reactions to erythromycin are rare and generally mild, though anaphylaxis has occurred in isolated cases. Some patients notice mild stomach discomfort after taking it by mouth, occasionally along with nausea or vomiting. This usually settles on its own within a few days, and the dose does not normally need to be lowered.
Cautions & Contraindications
Warnings & Precautions
Erosil should be used cautiously in patients with impaired liver function, since it is mainly eliminated from the body via the bile.
Contraindications
Known hypersensitivity to Erythromycin.
Pregnancy & Breastfeeding
Clinical and laboratory studies have not shown any evidence of birth defects or toxicity in humans. Even so, erythromycin should be used with caution in pregnant and breastfeeding women, as it crosses the placenta and passes into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Erythromycin has not been shown to be safe or effective for children under 12 years of age.
Overdose
If someone takes too much Erythromycin, stop the medicine. The unabsorbed drug should be removed promptly, and any other suitable measures should be started as well. Dialysis won't help here, because Erythromycin is not removed by peritoneal dialysis or haemodialysis.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Erythromycin below 25°C, away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Zuracin 125 mg/5 ml
What is Zuracin 125 mg/5 ml Powder For Suspension?
Zuracin 125 mg/5 ml Powder For Suspension is a medicine that contains Erythromycin. It is made by Rephco Pharmaceuticals Ltd. It belongs to the Anti-diarrhoeal antimicrobial drugs group of medicines.
What is Zuracin used for?
Zuracin is used for: Chronic Obstructive Pulmonary Disease, Cough, Bronchitis, Sinusitis, Pharyngitis, Fever, Respiratory Tract Infection, Skin and Soft Tissue Infection, Viral Infection, Otitis Media.
What are the side effects of Zuracin?
Allergic reactions to erythromycin are rare and generally mild, though anaphylaxis has occurred in isolated cases. Some patients notice mild stomach discomfort after taking it by mouth, occasionally along with nausea or vomiting.
Can I take Zuracin during pregnancy or while breastfeeding?
Clinical and laboratory studies have not shown any evidence of birth defects or toxicity in humans. Even so, erythromycin should be used with caution in pregnant and breastfeeding women, as it crosses the placenta and passes into breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Zuracin?
If someone takes too much Erythromycin, stop the medicine. The unabsorbed drug should be removed promptly, and any other suitable measures should be started as well. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Zuracin?
Store Erythromycin below 25°C, away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Zuracin?
Some medicines can interact with Erythromycin, for example: Lercanidipine Hydrochloride, Ebastine, Rivaroxaban, Artesunate, Olaparib, Terlipressin Acetate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Zuracin?
Zuracin is a prescription (Rx) medicine. Take it as your doctor advises.