Pricing
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Zultan is indicated for:
Pharmacology
Latanoprostene bunod is thought to lower intraocular pressure by helping aqueous humor drain out of the eye more freely, through both the trabecular meshwork and the uveoscleral routes. Intraocular pressure is a major risk factor for glaucoma getting worse, and it is one that can be changed. Bringing the pressure down lowers the risk of glaucomatous visual field loss.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual dose of Latanoprostene Bunod is one drop in the conjunctival sac of the affected eye or eyes, once daily in the evening. Don't use Latanoprostene Bunod ophthalmic solution, 0.024% more than once a day. Prostaglandin analogs given more often than that have been shown to lessen the intraocular pressure lowering effect.
If you are using Latanoprostene Bunod along with other topical eye medicines to lower intraocular pressure, put each one in at least five (5) minutes apart.
Side Effects
The following adverse reactions of Latanoprostene Bunod are described elsewhere in the labeling: pigmentation, eyelash changes, intraocular inflammation, macular edema, bacterial keratitis, and use with contact lens.
Cautions & Contraindications
Warnings & Precautions
Pigmentation Latanoprostene Bunod ophthalmic solution, 0.024% may cause changes to pigmented tissues. With prostaglandin analogs, the changes reported most often are increased pigmentation of the iris and of the tissue around the eye (the eyelid). Pigmentation is expected to keep increasing for as long as Latanoprostene Bunod is used. The change comes from more melanin in the melanocytes, not from a rise in the number of melanocytes. After Latanoprostene Bunod is stopped, the iris pigmentation is likely to be permanent, while the pigmentation of the tissue around the eye and the eyelash changes are likely to reverse in most patients. Patients who receive prostaglandin analogs, including Latanoprostene Bunod, should be told that pigmentation may increase and that some changes may be permanent. The long-term effects of increased pigmentation are not known. Iris colour change may not be noticeable for several months to years. Typically, the brown pigment around the pupil spreads outwards in rings towards the edge of the iris, and the whole iris or parts of it become more brownish. Neither nevi nor freckles of the iris appear to be affected by treatment. Treatment with Latanoprostene Bunod (Latanoprostene Bunod ophthalmic solution), 0.024% can be continued in patients who develop clearly increased iris pigmentation, but these patients should be examined regularly. Eyelash Changes Latanoprostene Bunod may slowly change the eyelashes and vellus hair in the treated eye. The lashes or hairs may grow longer and thicker, and there may be more of them. These changes usually reverse when treatment is stopped. Intraocular Inflammation Use Latanoprostene Bunod with caution in patients who have a history of intraocular inflammation (iritis/uveitis). It should generally not be used in patients with active intraocular inflammation, because it may make the condition worse. Macular Edema Macular edema, including cystoid macular edema, has been reported during treatment with prostaglandin analogs. Latanoprostene Bunod should be used with caution in aphakic patients, in pseudophakic patients with a torn posterior lens capsule, and in patients with known risk factors for macular edema. Bacterial Keratitis Bacterial keratitis has been reported with the use of multiple-dose containers of topical ophthalmic products. In most of these cases the containers had been contaminated by the patients without their noticing, and the patients had a concurrent corneal disease or a disruption of the ocular epithelial surface. Use with Contact Lens Remove contact lenses before using Latanoprostene Bunod, because it contains benzalkonium chloride. Lenses may be put back in 15 minutes after administration.
Contraindications
Don't use Latanoprostene Bunod eye drops if you are hypersensitive to any component of the preparation.
Pregnancy & Breastfeeding
There are no human data on the use of Latanoprostene Bunod during pregnancy, so any risk linked to the medicine can't be judged. Nothing is known either about whether Latanoprostene Bunod passes into human milk, what it might do to a breastfed infant, or whether it affects milk production. A mother should weigh the developmental and health benefits of breastfeeding against her own clinical need for the medicine, and also against any possible adverse effects it could have on the breastfed infant.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Latanoprostene bunod is not recommended for patients aged 16 years and younger. The concern is safety, because the pigmentation may increase after long-term chronic use.
Geriatric use: Doctors have not seen any overall clinical difference in safety or effectiveness between elderly patients and other adult patients.
Storage
Keep an unopened bottle of Latanoprostene Bunod in the refrigerator, at 2° to 8°C. Once you've opened it, the bottle can be kept at 2° to 25°C, and it stays usable for 8 weeks.
Common questions about Zultan 0.024%
What is Zultan 0.024% Ophthalmic Solution?
Zultan 0.024% Ophthalmic Solution is a medicine that contains Latanoprostene Bunod. It is made by Aristopharma Limited.
What is Zultan used for?
Zultan is used for: Hypertension, Glaucoma.
What are the side effects of Zultan?
The following adverse reactions of Latanoprostene Bunod are described elsewhere in the labeling: pigmentation, eyelash changes, intraocular inflammation, macular edema, bacterial keratitis, and use with contact lens.
Can I take Zultan during pregnancy or while breastfeeding?
There are no human data on the use of Latanoprostene Bunod during pregnancy, so any risk linked to the medicine can't be judged. Nothing is known either about whether Latanoprostene Bunod passes into human milk, what it might do to a breastfed infant, or whether it affects milk production. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Zultan?
Keep an unopened bottle of Latanoprostene Bunod in the refrigerator, at 2° to 8°C. Once you've opened it, the bottle can be kept at 2° to 25°C, and it stays usable for 8 weeks.
Do I need a prescription for Zultan?
Zultan is a prescription (Rx) medicine. Take it as your doctor advises.