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Other brands with the same active ingredient
These brands contain the same active ingredient (Glipizide). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Zitrol
Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Zitrol is indicated for:
Pharmacology
Glipizide brings blood glucose down by prompting the pancreas to release more insulin. This only works if the beta cells in the pancreas are still working properly. Outside the pancreas, glipizide also makes the body more sensitive to insulin and cuts down the amount of glucose the liver produces.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Like other oral hypoglycaemic agents, Glipizide has no fixed dose. It can be adjusted by checking blood glucose levels from time to time. A short course of Glipizide may be enough when blood glucose control is lost for a short while in people who are usually well controlled on diet alone. In general, take Glipizide about 30 minutes before a meal, so that it gives the greatest reduction in the rise of blood glucose after eating.
Initial dose
The recommended starting dose is 5 mg, given before breakfast. Elderly people and those with liver disease may be started on 2.5 mg.
Dosage adjustments
The dose can be changed every several days, in steps of 2.5 to 5 mg, depending on how the blood glucose responds. If one daily dose doesn't work well enough, splitting that dose might help. The maximum recommended once daily dose is 15 mg. Anything above 15 mg should usually be divided and given before meals that contain enough calories. The maximum recommended total daily dose is 40 mg.
Maintenance
Some people are controlled well on a once daily dose, while others respond better to divided doses. Total daily doses above 30 mg have been given safely on a twice daily basis to long term users. Most people can be stabilised on a dose between 2.5 and 30 mg daily.
Elderly, debilitated or malnourished patients, and those with impaired kidney or liver function, should have conservative initial and maintenance doses, to avoid hypoglycaemic reactions.
Many stable non-insulin-dependent diabetic patients who are on insulin can be safely moved to Glipizide, if the physician decides to do so.
For those already taking another oral hypoglycaemic agent, no transition period is needed when switching to Glipizide, as with other sulphonylureas. Watch them carefully, though, for any hypoglycaemic effect caused by the two drugs overlapping.
Pediatric use
Safety and effectiveness in children have not been established.
Side Effects
Diapizi's side effects are generally dose related, temporary, and tend to improve when the dose is lowered or the medicine is stopped. Gastrointestinal effects: Complaints such as nausea, diarrhoea, constipation and stomach pain have been reported. These are usually dose related and tend to go away once the dose is split up or reduced. Cholestatic jaundice can occur rarely with drugs of this kind, and Diapizi should be stopped if this happens. Dermatological effects: Allergic skin reactions, including redness, measles like or raised red rash, hives, itching and eczema, have been reported. These often clear up as treatment continues. If they do not, the medicine should be stopped. Haematologic effects: Low white blood cell count, agranulocytosis, low platelet count, haemolytic anaemia, aplastic anaemia and pancytopenia have been reported with sulphonylureas. Metabolic effects: Hepatic porphyria and disulphiram like reactions have been reported with sulphonylureas. Endocrine effects: Low blood sodium and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) have been reported with this and other sulphonylureas. Miscellaneous effects: Dizziness, drowsiness and headache have been reported in people treated with Diapizi. These are usually temporary and rarely require treatment to be stopped.
Cautions & Contraindications
Warnings & Precautions
Hypoglycaemia: All sulphonylurea drugs, including Diapizi, are capable of causing severe hypoglycaemia. Careful patient selection, correct dosing and clear instructions all help avoid hypoglycaemic episodes. In patients with renal or hepatic insufficiency, blood levels of Diapizi may rise, and the drug's gluconeogenic capacity may be reduced; both effects increase the risk of serious hypoglycaemic reactions. Elderly, debilitated or malnourished patients, as well as those with adrenal or pituitary insufficiency, are especially vulnerable to the glucose lowering effects of this drug. Patients should be advised to eat meals regularly and to avoid exercising excessively without taking in additional calories. Renal and hepatic disease: In patients with impaired renal or hepatic function, the metabolism and excretion of Diapizi may be slowed, which can lead to prolonged hypoglycaemia. Appropriate measures should be taken in such cases. Loss of blood glucose control: When a patient who is stable on an antidiabetic regimen is exposed to stress, such as fever, trauma, infection or surgery, control of blood glucose may be lost. In this situation, it may become necessary to stop Diapizi and start insulin instead. The effectiveness of any oral hypoglycaemic drug, including Diapizi, in lowering blood glucose to the desired level tends to decline in many patients over time. This may result from secondary failure, meaning either progression in the severity of the diabetes itself or a reduced response to the drug.
Contraindications
Glipizide should not be used by anyone who is hypersensitive to it or to any component of the product. It is also unsuitable for juvenile-onset diabetes and for severe or unstable "brittle" diabetes, or for diabetes complicated by ketosis and acidosis, major surgery, severe sepsis, or severe trauma. It should likewise be avoided in patients with severe renal, hepatic, or thyroid impairment, or with coexistent renal and hepatic disease.
Pregnancy & Breastfeeding
Pregnancy: Glipizide should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Prolonged, severe hypoglycaemia (lasting 4 to 10 days) has been reported in newborns whose mothers were taking a sulphonylurea (e.g., Glipizide) at the time of delivery. For this reason, if Glipizide is used during pregnancy, it should be stopped at least one month before the expected date of delivery.
Lactation: It is not known whether Glipizide passes into human breast milk, although some other sulphonylurea drugs are known to do so. Breastfeeding is therefore not recommended while taking this medication.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Store Glipizide below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Zitrol 5 mg
What is Zitrol 5 mg Tablet?
Zitrol 5 mg Tablet is a medicine that contains Glipizide. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Sulfonylureas group of medicines.
What is Zitrol used for?
Zitrol is used for: Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus, Diabetes Mellitus.
What are the side effects of Zitrol?
Diapizi's side effects are generally dose related, temporary, and tend to improve when the dose is lowered or the medicine is stopped. Gastrointestinal effects: Complaints such as nausea, diarrhoea, constipation and stomach pain have been reported.
Can I take Zitrol during pregnancy or while breastfeeding?
Pregnancy: Glipizide should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Prolonged, severe hypoglycaemia (lasting 4 to 10 days) has been reported in newborns whose mothers were taking a sulphonylurea (e.g., Glipizide) at the time of delivery. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Zitrol?
Store Glipizide below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Zitrol?
Some medicines can interact with Glipizide, for example: Fluconazole, Isoniazid, Chloramphenicol, Cyclophosphamide, Phenytoin, Fennel, Fenugreek, Cumin, Aniseed, Cumin & Dill Powder. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Zitrol?
Zitrol is a prescription (Rx) medicine. Take it as your doctor advises.