Pricing
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All price changes →Indications & Uses
Lidocaine + Epinephrine is used for dental infiltration anesthesia and for all dental nerve block techniques.
Pharmacology
This is a sterile, non-pyrogenic water-based solution that contains the local anaesthetic Lidocaine Hydrochloride with Epinephrine. Lidocaine is an amide-type local anaesthetic. It steadies the nerve cell membrane by blocking the movement of ions that is needed to start and carry nerve impulses, and that is how it produces its local anaesthetic effect. Lidocaine starts working quickly and its action lasts for an intermediate length of time. When the vasoconstrictor epinephrine is added, the action starts faster and lasts longer, and less of the medicine is absorbed into the blood from the injection site. With epinephrine, the effect lasts about one and a half to two hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Infiltration: the usual dose is 1 mL.
Nerve block: the usual dose is 1.5 to 2.0 mL.
The maximum recommended dose of Lidocaine Hydrochloride when it is given with Epinephrine is 500 mg. Children and elderly or debilitated patients need smaller doses.
Side Effects
Like other local anesthetics, Lidocaine + Epinephrine rarely causes adverse reactions in dental practice. When they do happen, they are usually the result of a very high blood concentration, caused by inadvertent intravascular injection, excessive dosage or rapid absorption. Occasionally the cause is hypersensitivity, idiosyncrasy or diminished tolerance in the patient. In these situations the effects are systemic and involve the central nervous system and/or the cardiovascular system. CNS reactions are excitatory and/or depressant. They may show as nervousness, dizziness, blurred vision and tremors, followed by drowsiness, convulsions, unconsciousness and possibly respiratory arrest. The excitatory reactions may be very brief, or they may not occur at all. In that case the first signs of toxicity may be drowsiness merging into unconsciousness and respiratory arrest. Cardiovascular reactions are depressant. They may show as hypotension, myocardial depression, bradycardia and possibly arrest. Allergic reactions are extremely rare. They may show as cutaneous lesion, urticaria, oedema or anaphylactic reactions. Skin testing to detect sensitivity is of doubtful value.
Cautions & Contraindications
Warnings & Precautions
As with other local anesthetics, Lidocaine + Epinephrine should be used with care in patients with epilepsy, impaired cardiac conduction and impaired respiratory function. The same care applies to patients with impaired hepatic function if the dose or the site of administration is likely to result in high blood levels. Facilities for resuscitation should be available whenever local anesthetics are given. The effect of a local anesthetic may be reduced if the injection is made into an inflamed or infected area. Solutions containing Epinephrine should be used with caution in patients with hypertension, cardiac disease, cerebrovascular insufficiency and thyrotoxicosis. Even so, solutions containing Epinephrine should be used where possible, because they prolong anesthesia and reduce systemic absorption. This matters most in highly vascular areas.
Contraindications
Don't give Lidocaine + Epinephrine to anyone with a known hypersensitivity to amide-type anesthetics. The vasoconstrictor must not be used for anesthesia of the fingers, toes, tip of the nose, ears or penis. And Lidocaine + Epinephrine should never be given intravenously.
Pregnancy & Breastfeeding
Animal studies have shown no evidence that Lidocaine + Epinephrine harms the fetus. Even so, as with any medicine, it shouldn't be given in early pregnancy unless the doctor considers the benefits to outweigh the risks.
It isn't known whether the medicine passes into breast milk, so take care when it is given to women who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Lidocaine + Epinephrine below 30°C, in a dry place and away from light. Keep it out of the reach of children.
Common questions about Z-Lidocaine Plus 2%+0.00125%
What is Z-Lidocaine Plus 2%+0.00125% Injection?
Z-Lidocaine Plus 2%+0.00125% Injection is a medicine that contains Lidocaine + Epinephrine. It is made by Ziska Pharmaceuticals Ltd. It belongs to the Local & Surface anesthesia group of medicines.
What is Z-Lidocaine Plus used for?
Lidocaine + Epinephrine is used for dental infiltration anesthesia and for all dental nerve block techniques.
What are the side effects of Z-Lidocaine Plus?
Like other local anesthetics, Lidocaine + Epinephrine rarely causes adverse reactions in dental practice. When they do happen, they are usually the result of a very high blood concentration, caused by inadvertent intravascular injection, excessive dosage or rapid absorption.
Can I take Z-Lidocaine Plus during pregnancy or while breastfeeding?
Animal studies have shown no evidence that Lidocaine + Epinephrine harms the fetus. Even so, as with any medicine, it shouldn't be given in early pregnancy unless the doctor considers the benefits to outweigh the risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Z-Lidocaine Plus?
Keep Lidocaine + Epinephrine below 30°C, in a dry place and away from light. Keep it out of the reach of children.
Do I need a prescription for Z-Lidocaine Plus?
Z-Lidocaine Plus is a prescription (Rx) medicine. Take it as your doctor advises.