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Indications & Uses
Pharmacology
Ofloxacin is a synthetic 4-fluoroquinolone antibacterial agent with bactericidal activity against a wide range of Gram-negative and Gram-positive organisms. It works by inhibiting DNA gyrase, an essential enzyme that plays a critical role in the duplication, transcription and repair of bacterial DNA. After oral administration, ofloxacin is rapidly and well absorbed from the GI tract, with a bioavailability of almost 100% in the tablet formulation. It is widely distributed into body tissues and fluids, and its half-life is about 4.6 to 6.9 hours. Up to 80% of an oral dose is eliminated in the urine as the parent compound within 48 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
General dosage recommendations: The dose of ofloxacin depends on the type and severity of the infection. For adults, the dosage range is 200 mg to 800 mg daily. Doses of up to 400 mg may be taken as a single dose, preferably in the morning; larger doses should be split into two divided doses. Ofloxacin tablets should be swallowed with liquid, and should not be taken within two hours of magnesium- or aluminium-containing antacids or iron preparations, because these can reduce the absorption of ofloxacin. Enteric fever: Adults, 200 mg every 12 hours for 5 days; children, 15 mg/kg/day in 2 divided doses for 3 days. Shigellosis: 400 mg as a single dose. Multi-drug-resistant tuberculosis: 400 mg twice daily together with conventional anti-tuberculosis drugs. Lower respiratory tract infection: 400 mg daily, increased if necessary to 400 mg twice daily. Uncomplicated urinary tract infections: a single dose of 200/400 mg. Uncomplicated urethral and cervical gonorrhoea: a single dose of 400 mg. Non-gonococcal urethritis and cervicitis: 400 mg daily in single or divided doses. Complicated urinary tract infection: 200/400 mg/day for 7 days. Impaired liver function: Excretion of ofloxacin may be reduced in patients with severe hepatic dysfunction. Children: Ofloxacin is usually not indicated for use in children or growing adolescents. Elderly: No dosage adjustment is required in the elderly. Ofloxacin eye and ear drops. Eye: Instill 1 drop in the affected eye(s) every 2 to 4 hours for the first two days, then 4 times daily. Treatment should not continue for more than ten days. Ear: Instill 1 to 2 drops in the affected ear(s) twice daily or as needed.
Side Effects
Flocet tablets are generally well tolerated, and side effects in clinical use have been uncommon. The most frequent adverse effects involve the gastrointestinal and central nervous systems. Gastrointestinal effects include nausea, vomiting, abdominal pain, diarrhoea, gastrointestinal distress and rash. Common central nervous system reactions are headache, dizziness and insomnia. Eye: Transient ocular irritation, burning, stinging, redness, itching or photophobia have been reported. Ear: Mild irritation or mild discomfort in the ear may occur. Symptoms of an allergic reaction include rash, itching, swelling or difficulty breathing.
Cautions & Contraindications
Warnings & Precautions
Patients taking Flocet should avoid unnecessary exposure to strong sunlight and should stay away from UV rays. Caution is advised when the drug is used in psychotic patients or in patients with a history of psychiatric illness. Prolonged use of the eye drops may lead to overgrowth of non-susceptible organisms, and prolonged use of the ear drops may lead to secondary infection.
Contraindications
Ofloxacin should not be used in patients with known hypersensitivity to 4-fluoroquinolone antibacterials. It is contraindicated in patients with a history of epilepsy or a lowered seizure threshold. Ofloxacin is usually contraindicated in children and growing adolescents, and in pregnant or breastfeeding women.
Pregnancy & Breastfeeding
Ofloxacin's safety in pregnancy has not been established. It may pass into breast milk, but data on this are lacking.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Ofloxacin between 15 to 30°C and away from light.
Drug Interactions
Common questions about Vista 0.3%
What is Vista 0.3% Ophthalmic Solution?
Vista 0.3% Ophthalmic Solution is a medicine that contains Ofloxacin. It is made by Aristopharma Limited. It belongs to the 4-Quinolone preparations group of medicines.
What is Vista used for?
Vista is used for: Chronic Obstructive Pulmonary Disease, Pneumonia, Bronchitis, Fever, Respiratory Tract Infection, Skin and Soft Tissue Infection, Typhoid Fever, Tuberculosis, Otitis Media, Conjunctivitis.
What are the side effects of Vista?
Flocet tablets are generally well tolerated, and side effects in clinical use have been uncommon. The most frequent adverse effects involve the gastrointestinal and central nervous systems.
Can I take Vista during pregnancy or while breastfeeding?
Ofloxacin's safety in pregnancy has not been established. It may pass into breast milk, but data on this are lacking. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Vista?
Keep Ofloxacin between 15 to 30°C and away from light.
Can I take other medicines with Vista?
Some medicines can interact with Ofloxacin, for example: Aluminium Hydroxide + Magnesium Hydroxide, Zinc, Iron, Magnesium, Carica Papaya Leaf Extract. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Vista?
Vista is a prescription (Rx) medicine. Take it as your doctor advises.