Indications & Uses
Vidalin F is indicated for:
Pharmacology
Vitamin B Complex & C + 20% Fat Emulsion IV is a sterile, freeze-dried powder of water-soluble vitamins, made up for infusion. It has all the important water-soluble vitamins in balanced amounts. These vitamins act as coenzymes of vital enzymes that are involved in key physiological processes, energy metabolism, and cell growth and replenishment, especially in brain and nerve cells. Vitamin C works as an antioxidant and helps in collagen formation. Because it is given intravenously, the combination acts promptly.
The fat emulsion part of Vitamin B Complex & C + 20% Fat Emulsion IV is a preparation of 20% refined soyabean oil, intended for use as an intravenous nutrient. It prevents Essential Fatty Acid Deficiency (EFAD) and corrects the clinical manifestations of EFAD.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Total parenteral nutrition (TPN): Vitamin B Complex & C + 20% Fat Emulsion is given as part of TPN, by IV infusion through a peripheral vein or through a central venous catheter. It should make up no more than 60% of the patient's total caloric intake. Carbohydrates and amino acids should supply the remaining 40% or more.
Adult: Start the infusion at 1 ml/min for the first 15 to 30 mins. If no adverse reactions occur, the rate can be raised to 2 ml/min. Don't exceed a daily dose of 2.5 g/kg.
Children: Start at 0.1 ml/min for the first 10 to 15 mins. If no adverse reactions occur, the rate can be raised to 1 g/kg in 4 hours. Don't exceed a daily dose of 3 g/kg.
Infants: Start at 0.5 g/kg/24 hours. The dose may then be increased according to the infant's ability to eliminate fat. The maximum recommended dose is 3 g/kg/24 hours.
Throw away whatever is left in an opened bottle and don't save it for later use. Don't use any bottle where the emulsion looks separated.
Side Effects
The combination of fat emulsion and water-soluble vitamins may cause a rise in body temperature (incidence <3%). Shivering, chills and nausea or vomiting are less common (incidence <1%). Other adverse events linked to 20% fat emulsion infusion are extremely rare, with less than one report of certain events per one million infusions. Hypersensitivity reactions (anaphylactic reaction, skin rash, urticaria), respiratory symptoms (tachypnoea) and circulatory effects (hypertension, hypotension) have been described. Thrombosis, haemolysis, reticulocytosis, abdominal pain, tiredness and priapism have also been reported, along with neurological adverse reactions. These include headaches, flushing, dyspnoea, slight pressure over the eyes and dizziness.
Cautions & Contraindications
Warnings & Precautions
Fat Emulsion and Water-soluble vitamin combination contains soya oil and egg lecithin, and these may rarely cause allergic reactions. Cross allergic reaction has been seen between soya-bean and peanut. Fat metabolism may be disturbed in conditions such as renal insufficiency, uncompensated diabetes, pancreatitis, certain forms of liver insufficiency, metabolic disorders and sepsis. Give the combination with caution, because a strong correlation exists between C-reactive protein and the agglutination of the Fat Emulsion and Water-soluble vitamin combination in seriously ill patients. Use caution too in neonates and premature infants with hyperbilirubinemia, and in cases with suspected pulmonary hypertension. In low birthweight infants, the risk of lipid infusions may outweigh the potential benefits, because defenses against infection are diminished further. In infants, infection and heparin administration may reduce the metabolism of lipids in peripheral tissues. Neonates on long term parenteral nutrition, particularly premature neonates, need their platelet count, liver function tests and serum triglyceride concentration monitored. If the Lyophilized Powder for Infusion is diluted with water-based solutions, protect the admixture from light. This isn't necessary when it is diluted with intralipid, since the fat emulsion protects it.
Contraindications
Don't give the Fat Emulsion and Water-soluble vitamin combination to anyone whose fat metabolism is severely disordered, for example in severe liver damage or acute shock. It also must not be given to people who are hypersensitive to egg, soya or peanut protein, or to any of the active substances or excipients in the preparation.
Pregnancy & Breastfeeding
Nobody has yet shown that the fetus or the nursing infant is completely safe with this combination. So the Fat Emulsion and water-soluble vitamin combination should be given with caution during pregnancy and while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
If the body can't clear the Fat Emulsion and Water-soluble vitamin combination properly, an overdose may lead to fat overload syndrome. It can also happen at the recommended infusion rates if the patient's condition changes suddenly, for example with impaired renal function or an infection. The syndrome is characterized by bone marrow depression, anemia, thrombocytopenia, hepatosplenomegaly, splenomegaly, hyperlipemia, fever, fat infiltration, focal seizures and shock. These symptoms are usually reversible once the infusion of the Fat Emulsion and Water-soluble vitamin combination is stopped.
No adverse effects have been reported from an overdose of water-soluble multivitamin, except in cases of extremely high parenteral doses. If the lyophilized powder for infusion is dissolved in another multivitamin injection, the possibility of hypervitaminosis A and D should be considered.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Before reconstitution, store Vitamin B Complex & C + 20% Fat Emulsion below 25°C in a dry place, and protect it from light. Keep it out of reach of children.
After reconstitution, the IV solution should be added to the infusion emulsion aseptically, immediately before the infusion starts.
Drug Interactions
Common questions about Vidalin F 20%
What is Vidalin F 20% IV Infusion?
Vidalin F 20% IV Infusion is a medicine that contains Vitamin B Complex & C + 20% Fat Emulsion. It is made by Popular Pharmaceuticals PLC. It belongs to the Specific combined vitamin preparations group of medicines.
What is Vidalin F used for?
Vidalin F is used for: Inflammatory Bowel Disease.
What are the side effects of Vidalin F?
The combination of fat emulsion and water-soluble vitamins may cause a rise in body temperature (incidence <3%). Shivering, chills and nausea or vomiting are less common (incidence <1%).
Can I take Vidalin F during pregnancy or while breastfeeding?
Nobody has yet shown that the fetus or the nursing infant is completely safe with this combination. So the Fat Emulsion and water-soluble vitamin combination should be given with caution during pregnancy and while breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Vidalin F?
If the body can't clear the Fat Emulsion and Water-soluble vitamin combination properly, an overdose may lead to fat overload syndrome. It can also happen at the recommended infusion rates if the patient's condition changes suddenly, for example with impaired renal function or an infection. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Vidalin F?
Before reconstitution, store Vitamin B Complex & C + 20% Fat Emulsion below 25°C in a dry place, and protect it from light. Keep it out of reach of children.
Can I take other medicines with Vidalin F?
Some medicines can interact with Vitamin B Complex & C + 20% Fat Emulsion, for example: Levodopa, Phenytoin, Folic Acid, Insulin (Human) 30/70, Heparin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Vidalin F?
Vidalin F is a prescription (Rx) medicine. Take it as your doctor advises.