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Other brands with the same active ingredient
These brands contain the same active ingredient (Solifenacin Succinate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Solif is used to relieve the symptoms of overactive bladder syndrome. These symptoms may include urge incontinence (a sudden, strong need to pass urine that leads to leakage), passing urine more often than usual, and a sense of urgency to urinate.
Pharmacology
Solifenacin works by blocking muscarinic receptors, acting as a competitive antagonist with its strongest affinity for the M3, M1, and M2 subtypes. In the bladder, most muscarinic receptors (about 80%) are the M2 type, with the remaining 20% being M3. By blocking M3 receptors, solifenacin stops the detrusor muscle from contracting, while its action on M2 receptors may further help relax smooth muscle in the bladder wall.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults and the elderly, the recommended dose is Solifenacin Succinate 5 mg once daily. If needed, the dose may be increased to Solifenacin Succinate 10 mg once daily.
Use in children: The safety and effectiveness of Solifenacin Succinate in children have not yet been established, so it should not be used in children.
Side Effects
Because of how Solif works, it may cause anticholinergic side effects that are usually mild or moderate. How often these effects occur depends on the dose. The most commonly reported adverse reaction with Solif is dry mouth. It occurred in 11% of patients taking 5 mg once daily, in 22% of patients taking 10 mg once daily and in 4% of patients taking placebo. Dry mouth was generally mild and only occasionally led to treatment being stopped. In general, adherence to the medicine was very high (approximately 99%) and approximately 90% of patients treated with Solif completed the full 12 week study period. Gastrointestinal disorders: very common, dry mouth; common, constipation, nausea, dyspepsia, abdominal pain; uncommon, gastroesophageal reflux disease, dry throat; rare, colonic obstruction, faecal impaction; very rare, vomiting. Infections and infestations: uncommon, urinary tract infection, cystitis. Nervous system disorders: uncommon, somnolence, dysgeusia; very rare, dizziness, headache. Psychiatric disorders: very rare, hallucinations. Eye disorders: common, blurred vision; uncommon, dry eyes. General disorders and administration site conditions: uncommon, fatigue, peripheral oedema. Respiratory, thoracic and mediastinal disorders: uncommon, nasal dryness. Skin and subcutaneous tissue disorders: uncommon, dry skin; very rare, pruritus, rash, urticaria. Renal and urinary disorders: uncommon, difficulty in micturition; rare, urinary retention.
Cautions & Contraindications
Warnings & Precautions
Other causes of frequent urination, such as heart failure or kidney disease, should be assessed before treatment with Solif begins. If a urinary tract infection is present, appropriate antibacterial therapy should be started. Solif should be used with caution in patients with clinically significant bladder outflow obstruction who are at risk of urinary retention, gastrointestinal obstructive disorders, a risk of decreased gastrointestinal motility, severe renal impairment (creatinine clearance 30 ml/min), or moderate hepatic impairment (Child-Pugh score of 7 to 9); doses should not exceed 5 mg in these patients. Caution is also needed when Solif is taken together with a potent CYP3A4 inhibitor such as ketoconazole, in patients with hiatus hernia or gastroesophageal reflux and/or those concurrently taking medicines (such as bisphosphonates) that can cause or worsen oesophagitis, and in patients with autonomic neuropathy. Safety and efficacy have not yet been established in patients whose detrusor overactivity has a neurogenic cause. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. The maximum effect of Solif can be determined after 4 weeks at the earliest.
Contraindications
Solifenacin should not be used by anyone who is hypersensitive (allergic) to solifenacin or to any of the other ingredients in the product. It is also contraindicated in people with myasthenia gravis, urinary retention, uncontrolled narrow-angle glaucoma, or a severe gastrointestinal condition (including toxic megacolon), and in patients undergoing haemodialysis. Solifenacin must not be given to patients with severe hepatic impairment, nor to patients with severe renal impairment or moderate hepatic impairment who are also being treated with a strong CYP3A4 inhibitor, such as ketoconazole.
Pregnancy & Breastfeeding
Pregnancy: There is no clinical data on women who became pregnant while using Solifenacin. Animal studies have not shown direct harm to fertility, foetal development, or delivery, but the risk to humans is not known. Solifenacin should be prescribed to pregnant women only with caution.
Breastfeeding: It is not known whether Solifenacin passes into human breast milk. In mice, however, Solifenacin and/or its breakdown products were found in milk and led to poor growth in nursing pups in a dose-dependent manner. For this reason, Solifenacin should not be used while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Patients with renal impairment
If the impairment is mild to moderate (creatinine clearance >30 ml/min), Solifenacin Succinate needs no dose adjustment. In severe renal impairment (creatinine clearance <30 ml/min), treat the patient with caution and give no more than 5 mg once daily.
Patients with hepatic impairment
No dose adjustment is needed when the impairment is mild. In moderate hepatic impairment (Child-Pugh score of 7 to 9), the patient should be treated with caution and receive no more than 5 mg once daily.
Potent inhibitors of cytochrome P450 3A4
When Solifenacin Succinate is given at the same time as Ketoconazole, or as therapeutic doses of other potent CYP3A4 inhibitors such as Ritonavir, Nelfinavir or Itraconazole, the maximum dose should be limited to 5 mg.
The tablet should be taken orally and swallowed whole with liquids. It can be taken with or without food.
Overdose
An overdose of Solifenacin Succinate can cause severe anticholinergic effects. The highest dose given by accident to a single patient was 280 mg over a 5 hour period. That patient had changes in mental status but did not need to be admitted to hospital.
If someone takes too much Solifenacin Succinate, treat with activated charcoal. Gastric lavage helps if it is done within 1 hour, but don't induce vomiting. As with other anticholinergics, the symptoms can be treated as follows:
Severe central anticholinergic effects such as hallucinations or pronounced excitation: treat with physostigmine or carbachol. Convulsions or pronounced excitation: treat with benzodiazepines. Respiratory insufficiency: treat with artificial respiration. Tachycardia: treat with beta-blockers. Urinary retention: treat with catheterisation. Mydriasis: treat with pilocarpine eye drops and/or place the patient in a dark room.
In an overdose, as with other antimuscarinics, take special care with patients who have a known risk of QT-prolongation (for example hypokalaemia, bradycardia, or taking medicines known to prolong the QT interval) and those with existing cardiac disease (for example myocardial ischaemia, arrhythmia, congestive heart failure).
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Solifenacin Succinate in a cool, dry place and away from light.
Drug Interactions
Common questions about Vesifen 5 5 mg
What is Vesifen 5 5 mg Tablet?
Vesifen 5 5 mg Tablet is a medicine that contains Solifenacin Succinate. It is made by Nuvista Pharma PLC. It belongs to the Anticholinergics (antimuscarinics)/ Anti-spasmodics group of medicines.
What is Vesifen 5 used for?
Solif is used to relieve the symptoms of overactive bladder syndrome. These symptoms may include urge incontinence (a sudden, strong need to pass urine that leads to leakage), passing urine more often than usual, and a sense of urgency to urinate.
What are the side effects of Vesifen 5?
Because of how Solif works, it may cause anticholinergic side effects that are usually mild or moderate. How often these effects occur depends on the dose.
Can I take Vesifen 5 during pregnancy or while breastfeeding?
Pregnancy: There is no clinical data on women who became pregnant while using Solifenacin. Animal studies have not shown direct harm to fertility, foetal development, or delivery, but the risk to humans is not known. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Vesifen 5?
An overdose of Solifenacin Succinate can cause severe anticholinergic effects. The highest dose given by accident to a single patient was 280 mg over a 5 hour period. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Vesifen 5?
Keep Solifenacin Succinate in a cool, dry place and away from light.
Can I take other medicines with Vesifen 5?
Some medicines can interact with Solifenacin Succinate, for example: Carbamazepine, Rifampicin, Digoxin, Itraconazole, Nelfinavir, Ritonavir. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Vesifen 5?
Vesifen 5 is a prescription (Rx) medicine. Take it as your doctor advises.