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Indications & Uses
Vertinor is indicated for:
Pharmacology
Betahistine works in more than one way. Meniere's disease is thought to come from a disruption of the fluid balance (endolymphatic fluid homeostasis) in the ear. Betahistine mainly acts as a histamine H1-receptor agonist. When H1-receptors in the inner ear are stimulated, the blood vessels widen, their permeability increases and the endolymphatic pressure falls. This action prevents rupture of the labyrinth, which can contribute to the hearing loss seen in Ménière's disease. Betahistine is also said to reduce the uneven functioning of the sensory vestibular organs and to increase blood flow in the vestibulocochlear region, and that relieves the symptoms of vertigo.
Betahistine also acts as a histamine H3-receptor antagonist. This increases the turnover of histamine from the postsynaptic histaminergic nerve receptors, which in turn increases H1-agonist activity. H3-receptor antagonism also raises the levels of neurotransmitters, including serotonin, in the brainstem. That inhibits the activity of the vestibular nuclei, so proper balance is restored and vertigo symptoms decrease.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults: Treatment usually starts at 8 to 16mg taken three times a day, preferably with meals. Maintenance doses generally fall between 24 and 48mg daily, and the daily dose should not go beyond 48mg. Dosage can be adjusted to suit each patient's needs, and improvement is sometimes seen only after a couple of weeks of treatment. No data are available for patients with liver or kidney impairment. Data in elderly patients are limited, so betahistine should be used with caution in this group.
Children and adolescents: Betahistine tablets are not recommended for anyone under 18, since safety and efficacy have not been established in this age group.
Side Effects
Betatin is generally well tolerated, and no serious side effects are known to occur with its use. Some people may experience mild issues such as stomach upset, headache, skin rash, or itching.
Cautions & Contraindications
Warnings & Precautions
Caution is warranted when treating patients who have, or have had, a peptic ulcer, since betahistine can occasionally bring on dyspepsia. The medicine should also be used carefully in people with bronchial asthma. Because it may worsen urticaria, skin rashes, or allergic rhinitis, betahistine should be prescribed cautiously to patients with these conditions, and the same caution applies in patients with severe hypotension. It should not be taken by patients with the rare hereditary conditions of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. Effects on driving and using machines: Betahistine has rarely been reported to cause drowsiness. Patients who notice this effect should avoid driving or operating machinery until it passes.
Contraindications
Betahistine should not be used by patients with phaeochromocytoma. Because it is a synthetic analogue of histamine, it can trigger the release of catecholamines from the tumour, which may cause severe hypertension. It should also be avoided in anyone with known hypersensitivity to the active substance.
Pregnancy & Breastfeeding
During Pregnancy: The safety of Betahistine for use in human pregnancy has not been fully established, though animal studies have shown no evidence of teratogenic effects. Before Betahistine is prescribed in pregnancy, its potential benefits should be carefully weighed against any risks.
During Lactation: Betahistine passes into the breast milk of nursing mothers, reaching concentrations similar to those seen in the mother's plasma. Whether these concentrations are toxic to the newborn is not known.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
An overdose of betahistine can cause nausea, vomiting, dyspepsia, ataxia and seizures. When someone took too much betahistine on purpose, more serious problems were seen, such as convulsion and pulmonary or cardiac complications. This happened especially when other drugs were also taken in overdose along with it. There is no specific antidote. Gastric lavage and symptomatic treatment are recommended.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Betahistine Dihydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Drug Interactions
Common questions about Vertinor 16 mg
What is Vertinor 16 mg Tablet?
Vertinor 16 mg Tablet is a medicine that contains Betahistine Dihydrochloride. It is made by Popular Pharmaceuticals PLC. It belongs to the Drugs used in meniere's diseases group of medicines.
What is Vertinor used for?
Vertinor is used for: Vertigo, Nausea and Vomiting.
What are the side effects of Vertinor?
Betatin is generally well tolerated, and no serious side effects are known to occur with its use. Some people may experience mild issues such as stomach upset, headache, skin rash, or itching.
Can I take Vertinor during pregnancy or while breastfeeding?
During Pregnancy: The safety of Betahistine for use in human pregnancy has not been fully established, though animal studies have shown no evidence of teratogenic effects. Before Betahistine is prescribed in pregnancy, its potential benefits should be carefully weighed against any risks. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Vertinor?
An overdose of betahistine can cause nausea, vomiting, dyspepsia, ataxia and seizures. When someone took too much betahistine on purpose, more serious problems were seen, such as convulsion and pulmonary or cardiac complications. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Vertinor?
Store Betahistine Dihydrochloride below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Can I take other medicines with Vertinor?
Some medicines can interact with Betahistine Dihydrochloride, for example: Salbutamol, Pyrimethamine, Dapsone, Ethanol 70%. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Vertinor is already among the lowest-priced brands of Betahistine Dihydrochloride at this strength.
Do I need a prescription for Vertinor?
Vertinor is a prescription (Rx) medicine. Take it as your doctor advises.