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Other brands with the same active ingredient
These brands contain the same active ingredient (Vericiguat). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
VERIVAS 10 is indicated for:
Pharmacology
Vericiguat is a stimulator of soluble guanylate cyclase (sGC), an enzyme in the nitric oxide (NO) signaling pathway. When NO binds to sGC, the enzyme makes cyclic guanosine monophosphate (cGMP) inside the cell. This cGMP acts as a second messenger and helps regulate vascular tone, cardiac contractility and cardiac remodeling. In heart failure, the body makes less NO and sGC is less active, and this may add to the dysfunction of the heart muscle and blood vessels. Vericiguat stimulates sGC directly, both independently of NO and together with NO, so the level of cGMP inside the cell rises. The result is relaxation of smooth muscle and widening of the blood vessels (vasodilation).
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
The usual starting dose of Vericiguat is 2.5 mg by mouth once a day, taken with food. Double the dose about every 2 weeks until the patient reaches the target maintenance dose of 10 mg once daily, as long as the patient tolerates it. If a patient can't swallow the tablet whole, Vericiguat may be crushed and mixed with water right before it is taken, or given as the physician directs.
Geriatric Patients
No dose adjustment of Vericiguat is needed in older patients. Safety and efficacy were not found to differ overall between patients aged 65 years and older and younger patients, but some older people may be more sensitive to the medicine, and this can't be ruled out.
Hepatic Impairment
No dose adjustment of Vericiguat is recommended in patients with mild or moderate hepatic impairment.
Renal Impairment
No dose adjustment of Vericiguat is recommended in patients with an estimated glomerular filtration rate (eGFR) of ≥15 mL/min/1.73m2 who are not on dialysis. Vericiguat has not been studied in patients with an eGFR of <15 mL/min/1.73m2 at the start of treatment, or in patients on dialysis.
Use in Children & Adolescents
Safety and effectiveness of Vericiguat have not been established in pediatric patients.
Side Effects
Common side effects of Vericiguat tablet are low blood pressure and a low red blood cell count (anemia).
Cautions & Contraindications
Warnings & Precautions
Vericiguat must not be given to a pregnant woman, because it may harm the baby. Before a woman who could become pregnant starts Vericiguat, she should have a pregnancy test, and pregnancy must be ruled out before treatment begins. To avoid pregnancy, women who could become pregnant must use effective contraception during treatment and for one month after stopping it.
Contraindications
Patients must not take Vericiguat together with any other soluble guanylate cyclase (sGC) stimulator.
Pregnancy & Breastfeeding
Pregnancy: Vericiguat must not be used in pregnancy, because it may cause fetal harm. Pregnancy should be ruled out before treatment starts. Women who could become pregnant must use effective contraception during treatment and for one month after stopping it.
Nursing mothers: There are no data on whether Vericiguat passes into human milk, what effect it has on a breastfed infant, or whether it changes milk production. Because breastfed infants could have serious adverse reactions to Vericiguat, women should be advised not to breastfeed while they are taking it.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There isn't much data on overdose with Vericiguat in people. Doses up to 10 mg have been studied. In one study of patients with preserved ejection fraction heart failure (left ventricular ejection fraction ≥45%), multiple doses of Vericiguat 15 mg were studied and were generally well tolerated. If an overdose happens, low blood pressure (hypotension) may result, and the patient should be given symptomatic treatment. Vericiguat is unlikely to be removed by hemodialysis because it is highly bound to protein.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Vericiguat at a temperature below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Common questions about VERIVAS 10 10 mg
What is VERIVAS 10 10 mg Tablet?
VERIVAS 10 10 mg Tablet is a medicine that contains Vericiguat. It is made by Popular Pharmaceuticals PLC. It belongs to the Stimulator of soluble guanylate cyclase group of medicines.
What is VERIVAS 10 used for?
VERIVAS 10 is used for: Heart Failure.
What are the side effects of VERIVAS 10?
Common side effects of Vericiguat tablet are low blood pressure and a low red blood cell count (anemia).
Can I take VERIVAS 10 during pregnancy or while breastfeeding?
Pregnancy: Vericiguat must not be used in pregnancy, because it may cause fetal harm. Pregnancy should be ruled out before treatment starts. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much VERIVAS 10?
There isn't much data on overdose with Vericiguat in people. Doses up to 10 mg have been studied. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store VERIVAS 10?
Store Vericiguat at a temperature below 30°C, and keep it away from light and moisture. Keep it out of the reach of children.
Do I need a prescription for VERIVAS 10?
VERIVAS 10 is a prescription (Rx) medicine. Take it as your doctor advises.