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Indications & Uses
Venlafaxine Hydrochloride is a serotonin and norepinephrine reuptake inhibitor (SNRI). Doctors prescribe it for these conditions: Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD) and Panic Disorder (PD).
Pharmacology
Doctors believe venlafaxine works against depression by strengthening the activity of certain neurotransmitters in the CNS. Preclinical studies show that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake. They are only weak inhibitors of dopamine reuptake.
In vitro, neither venlafaxine nor ODV has any significant affinity for muscarinic, histaminergic or α-1 adrenergic receptors. Activity at these receptors is hypothesized to be linked with the anticholinergic, sedative and cardiovascular effects seen with other psychotropic drugs. Venlafaxine and ODV also have no monoamine oxidase (MAO) inhibitory activity.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Depression: Venlafaxine is started at 75 mg daily, given in 2 divided doses. If needed, the doctor can raise this to 150 mg daily, still in 2 divided doses, after several weeks.
Severely depressed or hospitalized patients: The starting dose is 150 mg daily in 2 divided doses. If necessary, it can be increased in steps of up to 75 mg every 2 to 3 days, to a maximum of 376 mg daily, and then reduced gradually.
Generalised anxiety disorder: 75 mg daily as a single dose.
Side Effects
The side effects most often reported with Venlafaxine Hydrochloride are nausea, headache, insomnia, dry mouth, dizziness, constipation, sweating, nervousness and asthenia. Orthostatic has been seen occasionally. Other side effects that have been reported include anorexia, dyspepsia, abdominal pain, anxiety, sexual dysfunction, visual disturbances, vasodilatation, vomiting, tremor, chills, palpitations, agitation, rashes, convulsion and hypertension.
Cautions & Contraindications
Warnings & Precautions
Take care with Venlafaxine Hydrochloride in people who have a history of MI or unstable cardiac disease, or a history of seizure. The same care applies to hypomania or mania, to increased intraocular pressure or a risk of acute narrow-angle glaucoma, and to anyone at risk of bleeding. Renal and hepatic impairment also need caution, as do pregnancy and lactation. Don't stop the medicine suddenly. A gradual dose reduction is recommended rather than abrupt withdrawal. Patient counselling: Venlafaxine may impair the ability to drive or operate machinery.
Contraindications
Don't give venlafaxine hydrochloride to anyone who is hypersensitive to it or to any excipients in the formulation. It is also contraindicated in severe hepatic or renal impairment, and in pregnancy and breast-feeding.
Pregnancy & Breastfeeding
Venlafaxine needs caution in people with a history of myocardial infarction or unstable heart disease. Blood pressure monitoring is advisable if the dose goes above 200 mg daily. Care is also needed with a history of epilepsy, mania, and hepatic or renal impairment. Avoid abrupt withdrawal, and if venlafaxine has been taken for more than 1 week, withdraw it over at least 1 week. Glaucoma is another condition that calls for caution.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Venlafaxine Hydrochloride below 30° C, in a dry place and away from light. Keep it out of the reach of children.
Drug Interactions
Common questions about Venlax 37.5 mg
What is Venlax 37.5 mg Tablet?
Venlax 37.5 mg Tablet is a medicine that contains Venlafaxine Hydrochloride. It is made by General Pharmaceuticals Ltd. It belongs to the Serotonin-norepinephrine reuptake inhibitor (SNRI) group of medicines.
What is Venlax used for?
Venlafaxine Hydrochloride is a serotonin and norepinephrine reuptake inhibitor (SNRI). Doctors prescribe it for these conditions: Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD) and Panic Disorder (PD).
What are the side effects of Venlax?
The side effects most often reported with Venlafaxine Hydrochloride are nausea, headache, insomnia, dry mouth, dizziness, constipation, sweating, nervousness and asthenia. Orthostatic has been seen occasionally.
Can I take Venlax during pregnancy or while breastfeeding?
Venlafaxine needs caution in people with a history of myocardial infarction or unstable heart disease. Blood pressure monitoring is advisable if the dose goes above 200 mg daily. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Venlax?
Keep Venlafaxine Hydrochloride below 30° C, in a dry place and away from light. Keep it out of the reach of children.
Can I take other medicines with Venlax?
Some medicines can interact with Venlafaxine Hydrochloride, for example: Cimetidine. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Venlax is already among the lowest-priced brands of Venlafaxine Hydrochloride at this strength.
Do I need a prescription for Venlax?
Venlax is a prescription (Rx) medicine. Take it as your doctor advises.