Pricing
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All price changes →Indications & Uses
Tygacil is indicated for:
Pharmacology
Tigecycline, a glycylcycline, works by binding to the 30S ribosomal subunit of bacteria and blocking amino-acyl tRNA molecules from entering the A site of the ribosome. This stops protein translation, so amino acid residues cannot be added to growing peptide chains. Tigecycline carries a glycylamido group attached to the 9-position of minocycline, a substitution not found in any naturally occurring or semisynthetic tetracycline. This structural feature gives tigecycline distinct microbiologic properties: it is unaffected by the two major tetracycline resistance mechanisms, ribosomal protection and efflux, and has shown activity in vitro and in vivo against a broad range of bacterial pathogens. No cross resistance has been observed between tigecycline and other antibiotics. Tigecycline also remains active against organisms that resist other drug classes through mechanisms such as beta-lactamases (including extended spectrum beta-lactamases), target site modifications, macrolide efflux pumps, or changes to enzyme targets like gyrase and topoisomerase. In vitro studies have found no antagonism between tigecycline and other commonly used antibacterial drugs. Tigecycline is generally considered bacteriostatic.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Tigecycline's treatment duration should be based on how severe the infection is, where it's located, and how the patient responds clinically and bacteriologically. For complicated skin and skin structure infections or complicated intra-abdominal infections, Tigecycline is typically given for 5 to 14 days; for community-acquired bacterial pneumonia, treatment usually runs 7 to 14 days.
Adults: Treatment starts with an initial dose of 100 mg, followed by 50 mg every 12 hours. Each dose should be given as an intravenous infusion over about 30 to 60 minutes.
Pediatric use: Tigecycline's safety and effectiveness in pediatric patients under 18 years of age have not been established.
Geriatric use: Studies did not find any unexpected overall differences in safety or effectiveness between geriatric and younger patients.
Side Effects
The most common treatment-emergent side effects are nausea and vomiting, which generally occur during the first 1 to 2 days of therapy. Patients taking Tegalon have infrequently reported the following drug-related effects: inflammation and pain at the injection site, septic shock, allergic reaction, chills, thrombophlebitis, a slowed or a rapid heartbeat, vasodilatation, loss of appetite, dry mouth, low blood sugar, low blood sodium levels, prolonged prothrombin time, eosinophilia, thrombocytopenia, vaginal yeast infection, vaginitis, and leukorrhea.
Cautions & Contraindications
Warnings & Precautions
Tegalon belongs to the same structural family as Tetracycline-class antibiotics, so it should be used cautiously in anyone known to be hypersensitive to drugs of that class.
Contraindications
Tigecycline should not be used in patients who are hypersensitive to any of its components.
Pregnancy & Breastfeeding
Tigecycline, a tetracycline-class antibiotic, should only be given during pregnancy if the expected benefit is judged to outweigh the possible risk to the unborn baby. It should also be used with caution in mothers who are breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
There's no specific information on how to treat an overdose of Tigecycline. In healthy volunteers, a single 300 mg dose given intravenously over 60 minutes led to more nausea and vomiting.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Tigecycline in a refrigerator at 2-8°C before it is reconstituted, and don't freeze it. After reconstitution, it can be kept at room temperature for up to 24 hours. Of this, up to 6 hours can be in the vial, and the rest of the time in the intravenous bag. The reconstituted solution can also be kept in a refrigerator at 2°C to 8°C for up to 48 hours, as long as it is moved into the intravenous bag immediately after reconstitution.
Drug Interactions
Common questions about Tygacil 50 mg
What is Tygacil 50 mg IV Infusion?
Tygacil 50 mg IV Infusion is a medicine that contains Tigecycline. It is made by Radiant Pharmaceuticals Ltd. It belongs to the Tetracycline group of drugs group of medicines.
What is Tygacil used for?
Tygacil is used for: Pneumonia, Skin and Soft Tissue Infection.
What are the side effects of Tygacil?
The most common treatment-emergent side effects are nausea and vomiting, which generally occur during the first 1 to 2 days of therapy. Patients taking Tegalon have infrequently reported the following drug-related effects: inflammation and pain at the injection site, septic shock, allergic reaction, chills, thrombophlebitis, a slowed or a rapid heartbeat, vasodilatation, loss of appetite, dry mouth, low blood sugar, low blood sodium levels, prolonged prothrombin time, eosinophilia, thrombocytopenia, vaginal yeast infection, vaginitis, and leukorrhea.
Can I take Tygacil during pregnancy or while breastfeeding?
Tigecycline, a tetracycline-class antibiotic, should only be given during pregnancy if the expected benefit is judged to outweigh the possible risk to the unborn baby. It should also be used with caution in mothers who are breastfeeding. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Tygacil?
There's no specific information on how to treat an overdose of Tigecycline. In healthy volunteers, a single 300 mg dose given intravenously over 60 minutes led to more nausea and vomiting. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tygacil?
Keep Tigecycline in a refrigerator at 2-8°C before it is reconstituted, and don't freeze it. After reconstitution, it can be kept at room temperature for up to 24 hours.
Can I take other medicines with Tygacil?
Some medicines can interact with Tigecycline, for example: Digoxin, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Tygacil?
Tygacil is a prescription (Rx) medicine. Take it as your doctor advises.