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Indications & Uses
Mydrimide sterile eye drops are used to dilate (widen) the pupil so that the doctor can see into the back of the eye. They are used before eye examinations, such as cycloplegic refraction and examination of the fundus (the back of the eye). Mydrimide eye drops may also be used before and after eye surgery.
Pharmacology
Tropicamide is somewhat related in structure to atropine, and it causes the pupil to widen (mydriasis) and stops the eye from focusing up close (cycloplegia) by paralysing the parasympathetic system. It works as a parasympatholytic, meaning it blocks the parasympathetic nervous system from working. Acetylcholine is the neurotransmitter that normally acts at these receptor sites. Tropicamide competes with acetylcholine for the receptor sites and so blocks its action. The result is mydriasis, because the dilator pupillae is left unopposed, along with cycloplegia.
Tropicamide makes the pupil visibly larger about 5 minutes after it is put in. The pupil reaches its widest point after 20 to 25 minutes and returns to its normal size in roughly 6 hours. The effect starts quickly but wears off 45 to 60 minutes after the last drop. So the best time to do retinoscopy is about 20 minutes after the last drop goes in.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For refraction, instil 1 or 2 drops into the affected eye(s), and repeat after 5 minutes. If the patient cannot be examined within 20 to 30 minutes, one more drop may be instilled to prolong the mydriatic effect. For examination of the fundus, instil 1 drop 15 to 20 minutes before the examination.
Side Effects
A slight burning sensation may be felt for a short time after the drops go into the eye. In children, psychotic episodes, behavioural changes and cardio-respiratory collapse may occur. Tropicamide can affect how well you perform while driving or operating machinery, and it may slow your responses. It can also raise the pressure inside the eye, cause an allergic reaction, make the mouth feel dry, speed up the heartbeat (tachycardia) and cause headache.
Cautions & Contraindications
Warnings & Precautions
Where appropriate, giving an antidote (a miotic) after the examination should be considered. To reduce excessive absorption into the body, the patient should press on the tear duct of the treated eye with a finger for 2 to 3 minutes immediately after the eye drops are instilled. In older patients, mydriatic and cycloplegic drugs should generally be used with care.
Contraindications
Do not use in narrow-angle glaucoma or if allergic to any ingredient of the product.
Pregnancy & Breastfeeding
Pregnancy Category C. Tropicamide should be used during pregnancy only when clearly needed. Whether it passes into human breast milk is not known, so caution is advised when it is used by a breastfeeding woman, since many drugs do pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Signs of tropicamide overdose can include a red face, a fast pulse, dry mouth, less sweating and fewer secretions, and a rise in body temperature. How strong these symptoms are depends on how serious the overdose is.
If someone swallows the medicine by accident, contact an emergency doctor straight away. If needed, the effect on the eye can be reversed or neutralised with a miotic agent, which acts as the antidote.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Tropicamide at room temperature and away from light. Try not to use the contents more than one month after you first open the bottle.
Drug Interactions
Common questions about Tropigen 1%
What is Tropigen 1% Ophthalmic Solution?
Tropigen 1% Ophthalmic Solution is a medicine that contains Tropicamide. It is made by General Pharmaceuticals Ltd. It belongs to the Mydriatic and Cycloplegic agents group of medicines.
What is Tropigen used for?
Mydrimide sterile eye drops are used to dilate (widen) the pupil so that the doctor can see into the back of the eye. They are used before eye examinations, such as cycloplegic refraction and examination of the fundus (the back of the eye).
What are the side effects of Tropigen?
A slight burning sensation may be felt for a short time after the drops go into the eye. In children, psychotic episodes, behavioural changes and cardio-respiratory collapse may occur.
Can I take Tropigen during pregnancy or while breastfeeding?
Pregnancy Category C. Tropicamide should be used during pregnancy only when clearly needed. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Tropigen?
Signs of tropicamide overdose can include a red face, a fast pulse, dry mouth, less sweating and fewer secretions, and a rise in body temperature. How strong these symptoms are depends on how serious the overdose is. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Tropigen?
Keep Tropicamide at room temperature and away from light. Try not to use the contents more than one month after you first open the bottle.
Can I take other medicines with Tropigen?
Some medicines can interact with Tropicamide, for example: Tropicamide + Phenylephrine Hydrochloride, Atropine Sulphate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Tropigen?
Tropigen is a prescription (Rx) medicine. Take it as your doctor advises.