More from Trinon
Other strengths and forms by Renata PLC
Indications & Uses
Trinon is indicated for:
Pharmacology
Tretinoin's exact mechanism isn't fully understood, but current evidence suggests it works by making the cells lining the hair follicles less "sticky" to one another, which reduces the formation of microcomedones (the tiny plugs that develop into acne lesions). It also speeds up cell division and turnover in these follicular cells, helping to push out existing comedones, papules and pustules.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Apply Tretinoin cream sparingly over the whole affected area, once or twice a day. Clean the skin well and dry it before you put the cream on.
Tell the patient that it can take 6 to 8 weeks of treatment before any benefit shows. Moisturizers and cosmetics can be used during treatment, but not on the skin at the same time as the cream. Astringent toiletries should be avoided.
Side Effects
Initial application of Spotex may cause some burning, mild irritation, redness, or peeling at the site where it is applied. If irritation becomes severe or persistent, stop using it and consult your physician if needed.
Cautions & Contraindications
Warnings & Precautions
Avoid letting Spotex come into contact with the lips, mouth, eyes, eyelids, nostrils, or any other mucous membrane. If it does get into these areas, wash the area thoroughly with water. Use caution when applying the cream to sensitive areas of skin, such as the neck. Do not apply it to skin that is broken, affected by eczema, or sunburned.
Contraindications
Tretinoin should not be used by anyone who is highly sensitive to any of its ingredients. This cream is also not recommended for patients who have, or have had in their family, cutaneous epithelioma (a form of skin cancer).
Pregnancy & Breastfeeding
There is not enough evidence to confirm that Tretinoin cream is safe to use on the skin during pregnancy. However, when Tretinoin is taken systemically (by mouth), it has been shown to cause birth defects. For this reason, the cream should not be used during pregnancy or while breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: There are limited clinical data on Tretinoin in children. Of 15 pediatric patients (aged 1 to 16 years) treated with Tretinoin, 67% had a complete remission. Safety and effectiveness have not been established in children below 1 year of age. Some children get severe headache and pseudotumor cerebri, and they need analgesic treatment and a lumbar puncture for relief. Extra caution is recommended when treating children. The dose may be reduced if a child has serious and/or intolerable toxicity, but nobody has yet evaluated the efficacy and safety of Tretinoin at doses lower than 45 mg/m2 /day in the pediatric population.
Geriatric use: In the clinical studies of Tretinoin, 21.4% of the subjects were 60 and over. Researchers saw no overall difference in safety or effectiveness between these subjects and younger ones, and other reported clinical experience has not found any difference in response between elderly and younger patients. Even so, some older people may be more sensitive to the medicine, and this cannot be ruled out.
Overdose
No one has reported acute overdosage of tretinoin in humans. In patients with myelodysplastic syndrome or solid tumors, the maximal tolerated dose was 195 mg/m2/day. For pediatric patients it was lower, at 60 mg/m2/day.
Overdosage with other retinoids has been linked to transient headache, facial flushing, cheilosis, abdominal pain, dizziness and ataxia. These symptoms cleared quickly, with no apparent residual effects.
There is no specific treatment for an overdose of tretinoin. The patient should, however, be treated in a special hematological unit.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Tretinoin out of the reach of children. Store it in a cool, dry place and protect it from light.
Drug Interactions
Common questions about Trinon 50 mg
What is Trinon 50 mg Cream?
Trinon 50 mg Cream is a medicine that contains Tretinoin. It is made by Renata PLC. It belongs to the Topical retinoid and related preparations group of medicines.
What is Trinon used for?
Trinon is used for: Acne Vulgaris.
What are the side effects of Trinon?
Initial application of Spotex may cause some burning, mild irritation, redness, or peeling at the site where it is applied. If irritation becomes severe or persistent, stop using it and consult your physician if needed.
Can I take Trinon during pregnancy or while breastfeeding?
There is not enough evidence to confirm that Tretinoin cream is safe to use on the skin during pregnancy. However, when Tretinoin is taken systemically (by mouth), it has been shown to cause birth defects. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Trinon?
No one has reported acute overdosage of tretinoin in humans. In patients with myelodysplastic syndrome or solid tumors, the maximal tolerated dose was 195 mg/m2/day. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Trinon?
Keep Tretinoin out of the reach of children. Store it in a cool, dry place and protect it from light.
Can I take other medicines with Trinon?
Some medicines can interact with Tretinoin, for example: Minoxidil, Dithranol + Boric Acid + Salicylic Acid, Arsenic Trioxide, Benzoyl Peroxide. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Trinon?
Trinon is a prescription (Rx) medicine. Take it as your doctor advises.